一种从博落回果实中提取的新型具有细胞毒性的二苯并菲异喹啉生物碱。

A new cytotoxic benzophenanthridine isoquinoline alkaloid from the fruits of Macleaya cordata.

作者信息

Zou Hui-Liang, Li Hong-Yu, Liu Bai-Lian, Zhou Guang-Xiong

机构信息

a Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy Jinan University , Guangzhou 510632 , China.

出版信息

J Asian Nat Prod Res. 2015;17(8):856-60. doi: 10.1080/10286020.2015.1016000. Epub 2015 Mar 11.

DOI:10.1080/10286020.2015.1016000

PMID:25761206

Abstract

A new cytotoxic benzophenanthridine isoquinoline alkaloid, named cordatine (1), together with one known alkaloid 8-methoxydihydrochelerythrine (2), was isolated from the fruits of Macleaya cordata. The structure of the new compound was elucidated by spectroscopic methods including 1D and 2D NMR, HR-ESI-MS. Both compounds indicated significant cytotoxicity against MCF-7 and SF-268 cell lines.

摘要

从博落回果实中分离出一种新的具有细胞毒性的苯并菲异喹啉生物碱，命名为博落回碱（1），以及一种已知生物碱8-甲氧基二氢白屈菜红碱（2）。通过一维和二维核磁共振、高分辨电喷雾电离质谱等光谱方法阐明了新化合物的结构。两种化合物均对MCF-7和SF-268细胞系显示出显著的细胞毒性。