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一种分化刺激因子可诱导盘基网柄菌细胞对3':5'-环磷酸腺苷脉冲产生敏感性。

A differentiation stimulating factor induces cell sensitivity to 3':5'-cyclic AMP pulses in dictyostelium discoideum.

作者信息

Klein C, Darmon M

出版信息

Proc Natl Acad Sci U S A. 1976 Apr;73(4):1250-4. doi: 10.1073/pnas.73.4.1250.

DOI:10.1073/pnas.73.4.1250
PMID:177982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430240/
Abstract

During the first few hours of starvation, Dictyostelium discoideum amoebae excrete a macromolecule, probably a glycoprotein, which stimulates cell differentiation to aggregation competence. 3':5'-Cyclic AMP pulses, which mimic the chemotactic signal, and this factor (differentiation stimulating factor) are shown to exert a cooperative effect in inducing cell differentiation. Data suggest that the appearance of the factor determines the moment amoebae become responsive to cyclic AMP pulses.

摘要

在饥饿的最初几个小时里，盘基网柄菌变形虫会分泌一种大分子物质，可能是一种糖蛋白，它能刺激细胞分化为具备聚集能力的细胞。模拟趋化信号的3':5'-环磷酸腺苷脉冲与这种因子（分化刺激因子）在诱导细胞分化方面具有协同作用。数据表明，该因子的出现决定了变形虫对环磷酸腺苷脉冲产生反应的时刻。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/430240/b5f488e973f2/pnas00034-0279-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/430240/a861293e2aaa/pnas00034-0277-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/430240/199af07a6a43/pnas00034-0277-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/430240/b8af0a47aefb/pnas00034-0278-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/430240/b5f488e973f2/pnas00034-0279-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/430240/a861293e2aaa/pnas00034-0277-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/430240/199af07a6a43/pnas00034-0277-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/430240/b8af0a47aefb/pnas00034-0278-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a349/430240/b5f488e973f2/pnas00034-0279-a.jpg

相似文献

1
A differentiation stimulating factor induces cell sensitivity to 3':5'-cyclic AMP pulses in dictyostelium discoideum.一种分化刺激因子可诱导盘基网柄菌细胞对3':5'-环磷酸腺苷脉冲产生敏感性。
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1250-4. doi: 10.1073/pnas.73.4.1250.
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Rapid, transient methylation of four proteins in aggregative amoebae of Dictyostelium discoideum as a response to stimulation with cyclic AMP.盘基网柄菌聚集性变形虫中四种蛋白质的快速、短暂甲基化，作为对环磷酸腺苷刺激的反应。
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Evidence for a second chemotactic system in the cellular slime mold, Dictyostelium discoideum.在细胞黏菌盘基网柄菌中存在第二种趋化系统的证据。
J Bacteriol. 1970 Jun;102(3):682-7. doi: 10.1128/jb.102.3.682-687.1970.

引用本文的文献

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Eukaryot Cell. 2005 Jun;4(6):991-8. doi: 10.1128/EC.4.6.991-998.2005.
2
PSF and CMF, autocrine factors that regulate gene expression during growth and early development of Dictyostelium.PSF和CMF，在盘基网柄菌生长和早期发育过程中调节基因表达的自分泌因子。
Experientia. 1995 Dec 18;51(12):1124-34. doi: 10.1007/BF01944730.
3
cAMP and spore differentiation in Dictyostelium discoideum.

本文引用的文献

1
[Cell functions and change in cell function in the development of Dictyostelium discoideum. V. Stagespecific cell contact formation and its quantitative evaluation].[盘基网柄菌发育过程中的细胞功能及细胞功能变化。V. 阶段特异性细胞接触形成及其定量评估]
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Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture.
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Developmental regulation of the alpha-mannosidase gene in Dictyostelium discoideum: control is at the level of transcription and is affected by cell density.盘基网柄菌中α-甘露糖苷酶基因的发育调控：调控发生在转录水平，且受细胞密度影响。
Mol Cell Biol. 1991 Jun;11(6):3339-47. doi: 10.1128/mcb.11.6.3339-3347.1991.
细胞黏菌盘基网柄菌的黏变形体在无菌培养中的生长。
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4
The acrasin activity of adenosine-3',5'-cyclic phosphate.3',5'-环磷酸腺苷的聚集素活性。
Proc Natl Acad Sci U S A. 1967 Sep;58(3):1152-4. doi: 10.1073/pnas.58.3.1152.
5
Dynamics of antigenic membrane sites relating to cell aggregation in Dictyostelium discoideum.盘基网柄菌中与细胞聚集相关的抗原性膜位点的动态变化
J Cell Biol. 1973 Mar;56(3):647-58. doi: 10.1083/jcb.56.3.647.
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Induction of lymphocyte transformation by sequential treatment with neuraminidase and galactose oxidase.通过神经氨酸酶和半乳糖氧化酶的序贯处理诱导淋巴细胞转化
Proc Natl Acad Sci U S A. 1973 Jun;70(6):1824-7. doi: 10.1073/pnas.70.6.1824.
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Cyclic AMP phosphodiesterase and its inhibitor in slime mould development.环磷酸腺苷磷酸二酯酶及其抑制剂在黏菌发育中的作用
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Wave propagation in the early stages of aggregation of cellular slime molds.细胞黏菌聚集早期的波传播
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Adenosine-3',5'-phosphate: identification as acrasin in a species of cellular slime mold.腺苷 - 3',5'-磷酸：在一种细胞黏菌中被鉴定为聚集素。
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10
Acrasin, Acrasinase, and the sensitivity to acrasin in Dictyostelium discoideum.盘基网柄菌中的聚集素、聚集素酶以及对聚集素的敏感性
Dev Biol. 1969 Jul;20(1):72-87. doi: 10.1016/0012-1606(69)90005-0.