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环磷酸腺苷诱导细胞黏菌盘基网柄菌中柄细胞分化

Induction of stalk cell differentiation by cyclic AMP in the cellular slime mold Dictyostelium discoideum.

作者信息

Bonner J T

出版信息

Proc Natl Acad Sci U S A. 1970 Jan;65(1):110-3. doi: 10.1073/pnas.65.1.110.

DOI:10.1073/pnas.65.1.110
PMID:4313192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC286198/
Abstract

Cyclic AMP, which is a cell attractant (acrasin) for Dictyostelium discoideum, will cause isolated, unaggregated cells to turn directly into stalk cells containing thick celluloselike walls and large vacuoles. From previous work we know that in the cell mass, acrasin is produced solely in the region of stalk formation during fruiting, that stalk formation involves a high level of catabolism, and that cyclic AMP stimulates catabolic enzymes in other systems. These facts obviously suggest that in the development of D. discoideum, cyclic AMP might be a key factor in stalk cell differentiation.

摘要

环磷酸腺苷（Cyclic AMP）是盘基网柄菌（Dictyostelium discoideum）的一种细胞引诱剂（聚集素），它会使分离的、未聚集的细胞直接转变为含有厚纤维素样壁和大液泡的柄细胞。从之前的研究工作中我们了解到，在细胞团中，聚集素仅在子实体形成过程中的柄形成区域产生，柄的形成涉及高水平的分解代谢，并且环磷酸腺苷在其他系统中会刺激分解代谢酶。这些事实显然表明，在盘基网柄菌的发育过程中，环磷酸腺苷可能是柄细胞分化的关键因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c19/286198/50e26c0b2e15/pnas00092-0132-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c19/286198/50e26c0b2e15/pnas00092-0132-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c19/286198/50e26c0b2e15/pnas00092-0132-a.jpg

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本文引用的文献

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