The National Research Centre for the Working Environment, Lersø Parkalle 105, 2100 København Ø, Denmark.
Chemosphere. 2010 Sep;80(11):1377-86. doi: 10.1016/j.chemosphere.2010.06.004. Epub 2010 Jul 1.
The use of nanofilm spray products (NFPs) has been associated with a number of severe cases of airway injuries; however, the causative agents are unknown. To identify possible causative agents, 10 products from three different suppliers have been analysed using two mass spectrometric methods: (1) ESI-MS and ESI-MS/MS; (2) GC-MS and GC-MS/MS. The 10 products could be classified into three groups (NFPs 1-3). NFP 1 and NFP 2 contained hydrolysates and condensates of the organo-functionalized silanes 1H,1H,2H,2H-perfluorooctyl triisopropoxysilane and hexadecyl triethoxysilane, respectively. NFP 3 contained non-ionic detergents and abrasive as active ingredients. To verify the fluorosilane solution in NFP 1, a synthetic NFP 1 was prepared by hydrolysis and condensation of 1H,1H,2H,2H-perfluorooctyl triethoxysilane. After about 1month in acidic 2-propanol substitution of the ethoxy groups with isopropoxy groups had taken place and all silane was converted to disiloxanes, trisiloxanes and tetrasiloxanes.
纳米薄膜喷雾产品（NFPs）的使用与许多严重的气道损伤病例有关；然而，其致病因子尚不清楚。为了确定可能的致病因子，使用两种质谱方法（1：ESI-MS 和 ESI-MS/MS；2：GC-MS 和 GC-MS/MS）对来自三个不同供应商的 10 种产品进行了分析。这 10 种产品可以分为三组（NFPs1-3）。NFP1 和 NFP2 分别含有有机官能化硅烷 1H、1H、2H、2H-全氟辛基三异丙氧基硅烷和十六烷基三乙氧基硅烷的水解产物和缩合物。NFP3 含有非离子型清洁剂和磨料作为有效成分。为了验证 NFP1 中的氟硅烷溶液，通过 1H、1H、2H、2H-全氟辛基三乙氧基硅烷的水解和缩合制备了合成的 NFP1。大约 1 个月后，在酸性异丙醇中，乙氧基与异丙氧基发生取代反应，所有硅烷都转化为二硅氧烷、三硅氧烷和四硅氧烷。
