猴病毒40的基因组。

The genome of simian virus 40.

作者信息

Reddy V B, Thimmappaya B, Dhar R, Subramanian K N, Zain B S, Pan J, Ghosh P K, Celma M L, Weissman S M

出版信息

Science. 1978 May 5;200(4341):494-502. doi: 10.1126/science.205947.

DOI:10.1126/science.205947

PMID:205947

Abstract

The nucleotide sequence of SV40 DNA was determined, and the sequence was correlated with known genes of the virus and with the structure of viral messenger RNA's. There is a limited overlap of the coding regions for structural proteins and a complex pattern of leader sequences at the 5' end of late messenger RNA. The sequence of the early region is consistent with recent proposals that the large early polypeptide of SV40 is encoded in noncontinguous segments of DNA.

摘要

测定了SV40 DNA的核苷酸序列，并将该序列与病毒的已知基因以及病毒信使RNA的结构进行了关联。结构蛋白的编码区域存在有限的重叠，晚期信使RNA 5'端的前导序列模式复杂。早期区域的序列与最近提出的SV40大早期多肽由DNA的不连续片段编码的观点一致。