Department of Physiology and Biomedical Engineering,Mayo Clinic, Rochester, MN 55905 USA.
IEEE Trans Biomed Eng. 2011 Feb;58(2):235-42. doi: 10.1109/TBME.2010.2053928. Epub 2010 Jun 28.
This paper reports shear stiffness and viscosity "virtual biopsy" measurements of the three excised noncancerous human prostates using a new tool known as shear wave dispersion ultrasound vibrometry (SDUV) in vitro. Improved methods for prostate guided-biopsy are required to effectively guide needle biopsy to the suspected site. In addition, tissue stiffness measurement helps in identifying a suspected site to perform biopsy because stiffness has been shown to correlate with pathologies, such as cancerous tissue. More importantly, early detection of prostate cancer may guide minimally invasive therapy and eliminate insidious procedures. In this paper, "virtual biopsies" were taken in multiple locations in three excised prostates; SDUV shear elasticity and viscosity measurements were performed at the selected "suspicious" locations within the prostates. SDUV measurements of prostate elasticity and viscosity are generally in agreement with preliminary values previously reported in the literature. It is, however, important to emphasize here that the obtained viscoelastic parameters values are local, and not a mean value for the whole prostate.
本文报告了使用一种称为剪切波频散超声振动测量（SDUV）的新工具对三个切除的非癌人类前列腺进行剪切刚度和粘度“虚拟活检”测量的结果。需要改进前列腺引导活检的方法，以便有效地将针活检引导至可疑部位。此外，组织硬度测量有助于确定可疑部位进行活检，因为已经证明硬度与癌症等病变相关。更重要的是，前列腺癌的早期检测可以指导微创治疗并消除阴险的程序。在本文中，在三个切除的前列腺中多处进行了“虚拟活检”；在前列腺内选定的“可疑”位置进行了 SDUV 剪切弹性和粘度测量。前列腺弹性和粘度的 SDUV 测量结果通常与文献中先前报道的初步值一致。然而，在这里重要的是要强调，所获得的粘弹性参数值是局部的，而不是整个前列腺的平均值。
