Mitri Farid G, Davis Brian J, Alizad Azra, Greenleaf James F, Wilson Torrence M, Mynderse Lance A, Fatemi Mostafa
Department of Physiology and Biomedical Engineering, Ultrasound Research Laboratory, Mayo Clinic, Rochester, MN 55905, USA.
IEEE Trans Biomed Eng. 2008 Nov;55(11):2584-92. doi: 10.1109/TBME.2008.2001284.
The objective of this research is to prospectively evaluate the feasibility of vibroacoustography (VA) imaging in monitoring prostate cryotherapy in an ex vivo model. Baseline scanning of an excised human prostate is accomplished by a VA system apparatus in a tank of degassed water. Alcohol and dry ice mixture are used to freeze two prostate tissue samples. The frozen prostates are subsequently placed within the water tank at 27 degrees C and rescanned. VA images were acquired at prescribed time intervals to characterize the acoustic properties of the partially frozen tissue. The frozen prostate tissue appears in the images as hypoemitting signal. Once the tissue thaws, previously frozen regions show coarser texture than prior to freezing. The margin of the frozen tissue is delineated with a well-defined rim. The thawed cryolesions show a different contrast compared with normal unfrozen prostate. In conclusion, this pilot study shows that VA produces clear images of a frozen prostate at different temperature stages. The frozen tissue appears as a uniform region with well-defined borders that are readily identified. These characteristic images should allow safer and more efficient application of prostatic cryosurgery. These results provide substantial motivation to further investigate VA as a potential modality to monitor prostate cryotherapy intraoperatively.
本研究的目的是前瞻性评估振动声学成像（VA）在离体模型中监测前列腺冷冻治疗的可行性。通过VA系统设备在脱气水箱中对切除的人体前列腺进行基线扫描。使用酒精和干冰混合物冷冻两个前列腺组织样本。随后将冷冻的前列腺置于27摄氏度的水箱中并重新扫描。按规定的时间间隔采集VA图像，以表征部分冷冻组织的声学特性。冷冻的前列腺组织在图像中表现为低发射信号。一旦组织解冻，先前冷冻的区域显示出比冷冻前更粗糙的质地。冷冻组织的边缘由清晰的边缘勾勒出来。与正常未冷冻的前列腺相比，解冻后的冷冻损伤显示出不同的对比度。总之，这项初步研究表明，VA能在不同温度阶段产生冷冻前列腺的清晰图像。冷冻组织表现为边界清晰的均匀区域，易于识别。这些特征性图像应能使前列腺冷冻手术应用更安全、更高效。这些结果为进一步研究VA作为术中监测前列腺冷冻治疗的潜在方式提供了充分的动力。
