全国调查人群中老年居民维生素 D 水平与抑郁症状之间的关系。
Relationship between vitamin D levels and depressive symptoms in older residents from a national survey population.
机构信息
Department of Health Service and Population Research, King's College London (Institute of Psychiatry), London, United Kingdom.
出版信息
Psychosom Med. 2010 Sep;72(7):608-12. doi: 10.1097/PSY.0b013e3181e9bf15. Epub 2010 Jul 1.
OBJECTIVE
To investigate the association between vitamin D deficiency and depressive symptoms in a national community sample of older people. Vitamin D deficiency is common in older people with potential effects on mood.
METHODS
Data were analyzed from 2070 participants aged ≥65 years who had participated in the 2005 Health Survey for England. Serum 25-hydroxy vitamin D (25(OH)D) levels and depressive symptoms (Geriatric Depression Scale) had been measured. Covariates included age, sex, social class, season of examination, and physical health status.
RESULTS
Depressive symptoms were associated with clinical vitamin D deficiency (25(OH)D levels <10 ng/mL; present in 9.8%) independent of other covariates but not with broader deficiency states. This association was not modified by season of examination.
CONCLUSION
Vitamin D deficiency is associated with late-life depression in northern latitudes.
目的
在一个全国性的老年人社区样本中，调查维生素 D 缺乏与抑郁症状之间的关联。维生素 D 缺乏在老年人中很常见，可能对情绪产生影响。
方法
对参加了 2005 年英格兰健康调查的 2070 名年龄≥65 岁的参与者进行了数据分析。测量了血清 25-羟维生素 D（25(OH)D）水平和抑郁症状（老年抑郁量表）。协变量包括年龄、性别、社会阶层、检查季节和身体健康状况。
结果
抑郁症状与临床维生素 D 缺乏（25(OH)D 水平<10ng/mL；存在于 9.8%的患者中）相关，与其他协变量无关，但与更广泛的缺乏状态无关。这种关联不受检查季节的影响。
结论
在高纬度地区，维生素 D 缺乏与晚年抑郁有关。
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