抑郁症与维生素D：一种特殊的关系。
Depression and Vitamin D: A Peculiar Relationship.
作者信息
Saji Parel Nisha, Krishna Parimi Vamsi, Gupta Anuradha, Uthayaseelan Kamsika, Uthayaseelan Kivonika, Kadari Monika, Subhan Muhammad, Kasire Sripada Preetham
机构信息
Family Medicine, Tbilisi State Medical University, Tbilisi, GEO.
Internal Medicine, Jagadguru Jayadeva Murugarajendra Medical College, Davanagere, IND.
出版信息
Cureus. 2022 Apr 21;14(4):e24363. doi: 10.7759/cureus.24363. eCollection 2022 Apr.
Abstract
Depression is a psychiatric disorder characterized by various symptoms that can impact one's quality of life. Vitamin D, a fat-soluble vitamin, is well-known for its role in bone health, and research on its effects on mental health has only recently emerged. Vitamin D deficiency is widespread worldwide, and it has been linked to an increased risk of depression. In this article, we have discussed different hypotheses that explain the role of vitamin D in gene expression and its effects on neurotransmitters and different brain functions. We have reviewed literature that shows us that Vitamin D deficiency is a risk factor for depression and explored studies that show us the effects of using or supplementing Vitamin D in preventing depression among various populations.
摘要
抑郁症是一种精神障碍，其特征是有各种会影响一个人生活质量的症状。维生素D是一种脂溶性维生素，因其在骨骼健康方面的作用而广为人知，而关于其对心理健康影响的研究直到最近才出现。维生素D缺乏在全球范围内普遍存在，并且它与抑郁症风险增加有关。在本文中，我们讨论了不同的假说，这些假说解释了维生素D在基因表达中的作用及其对神经递质和不同脑功能的影响。我们回顾了相关文献，这些文献向我们表明维生素D缺乏是抑郁症的一个风险因素，并探讨了相关研究，这些研究向我们展示了在不同人群中使用或补充维生素D预防抑郁症的效果。
相似文献
1
Depression and Vitamin D: A Peculiar Relationship.抑郁症与维生素D：一种特殊的关系。
Cureus. 2022 Apr 21;14(4):e24363. doi: 10.7759/cureus.24363. eCollection 2022 Apr.
2
Effect of an vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients - a randomized controlled trial: study protocol.维生素 D 缺乏对儿童和青少年精神科患者抑郁症状的影响 - 一项随机对照试验：研究方案。
BMC Psychiatry. 2018 Mar 1;18(1):57. doi: 10.1186/s12888-018-1637-7.
3
Vitamin D and Depression: The Evidence from an Indirect Clue to Treatment Strategy.维生素 D 与抑郁症：从间接治疗线索中获得的证据。
Curr Drug Targets. 2018;19(8):888-897. doi: 10.2174/1389450118666170913161030.
4
Vitamin D Supplementation and Mental Health in Multiple Sclerosis Patients: A Systematic Review.维生素 D 补充与多发性硬化症患者的心理健康：系统评价。
Nutrients. 2021 Nov 24;13(12):4207. doi: 10.3390/nu13124207.
5
Potential Role of Vitamin D for the Management of Depression and Anxiety.维生素 D 在抑郁症和焦虑症管理中的潜在作用。
CNS Drugs. 2019 Jul;33(7):619-637. doi: 10.1007/s40263-019-00640-4.
6
Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review.维生素 D 补充对糖尿病患者心理健康的影响：系统评价。
Nutrients. 2021 Oct 20;13(11):3678. doi: 10.3390/nu13113678.
7
[Psychiatric manifestations of vitamin B12 deficiency: a case report].[维生素B12缺乏的精神症状：一例报告]
Encephale. 2003 Nov-Dec;29(6):560-5.
8
The Impact of Vitamin D on Neuropsychiatric Disorders.维生素D对神经精神障碍的影响。
Cureus. 2023 Oct 26;15(10):e47716. doi: 10.7759/cureus.47716. eCollection 2023 Oct.
9
Vitamin D is a potential antidepressant in psychiatric outpatients
.维生素D对精神科门诊患者而言可能是一种抗抑郁剂。
Int J Clin Pharmacol Ther. 2018 Dec;56(12):585-596. doi: 10.5414/CP203309.
10
Clinical relevance of optimizing vitamin D status in soldiers to enhance physical and cognitive performance.优化士兵维生素D状态以提高身体和认知表现的临床相关性。
J Spec Oper Med. 2014 Spring;14(1):58-66. doi: 10.55460/52YL-XU05.
引用本文的文献
1
Association of serum 25-hydroxyvitamin D with the risk of depression in individuals with prediabetes and diabetes: A prospective cohort study.血清25-羟基维生素D与糖尿病前期和糖尿病患者抑郁风险的关联：一项前瞻性队列研究。
J Nutr Health Aging. 2025 Jun;29(6):100556. doi: 10.1016/j.jnha.2025.100556. Epub 2025 Apr 14.
2
An Observational Study on the Association Between Nutritional Intake and Mental Health Among Older Adults in Rural Areas.农村老年人营养摄入与心理健康关系的观察性研究
Nurs Health Sci. 2025 Mar;27(1):e70080. doi: 10.1111/nhs.70080.
3
Evaluating the association of depressive symptoms on serum folate and erythrocyte folate levels based on the 2017-2020 NHANES database.基于2017 - 2020年美国国家健康与营养检查调查（NHANES）数据库评估抑郁症状与血清叶酸和红细胞叶酸水平之间的关联。
Front Nutr. 2025 Feb 10;12:1505700. doi: 10.3389/fnut.2025.1505700. eCollection 2025.
4
Is Serum Vitamin D Associated with Depression or Anxiety in Ante- and Postnatal Adult Women? A Systematic Review with Meta-Analysis.血清维生素 D 与产前和产后成年女性的抑郁或焦虑有关吗？一项系统评价与荟萃分析。
Nutrients. 2024 Oct 26;16(21):3648. doi: 10.3390/nu16213648.
5
Knowledge, attitude, and practice of depression among university students.大学生抑郁的知识、态度和实践。
Brain Behav. 2024 Sep;14(9):e70030. doi: 10.1002/brb3.70030.
6
Omega-3 Polyunsaturated Fatty Acids in Depression.ω-3 多不饱和脂肪酸与抑郁症
Int J Mol Sci. 2024 Aug 8;25(16):8675. doi: 10.3390/ijms25168675.
7
Does Vitamin D3 Supplementation Improve Depression Scores among Rural Adolescents? A Randomized Controlled Trial.维生素 D3 补充是否能改善农村青少年的抑郁评分？一项随机对照试验。
Nutrients. 2024 Jun 11;16(12):1828. doi: 10.3390/nu16121828.
8
Systematic Review and Meta-analysis of the Association Between Malnutrition and Risk of Depression in the Elderly.老年人营养不良与抑郁风险关联的系统评价和荟萃分析
Alpha Psychiatry. 2024 Mar 1;25(2):183-189. doi: 10.5152/alphapsychiatry.2024.231336. eCollection 2024 Mar.
9
Analysis of MicroRNA-Transcription Factors Co-Regulatory Network Linking Depression and Vitamin D Deficiency.分析连接抑郁症和维生素 D 缺乏的 microRNA-转录因子共同调控网络。
Int J Mol Sci. 2024 Jan 17;25(2):1114. doi: 10.3390/ijms25021114.
10
Difference in Levels of Vitamin D between Indoor and Outdoor Athletes: A Systematic Review and Meta-Analysis.室内和室外运动员之间维生素 D 水平的差异：系统评价和荟萃分析。
Int J Mol Sci. 2023 Apr 20;24(8):7584. doi: 10.3390/ijms24087584.
本文引用的文献
1
The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review.维生素D摄入与状态对儿童心理健康的影响：一项系统综述
Nutrients. 2021 Mar 16;13(3):952. doi: 10.3390/nu13030952.
2
Associations of vitamin D deficiency with MRI markers of brain health in a community sample.社区样本中维生素 D 缺乏与大脑健康 MRI 标志物的关联。
Clin Nutr. 2021 Jan;40(1):72-78. doi: 10.1016/j.clnu.2020.04.027. Epub 2020 Apr 25.
3
The relationship between Vitamin D and depressive disorders.维生素 D 与抑郁障碍的关系。
Riv Psichiatr. 2019 Nov-Dec;54(6):229-234. doi: 10.1708/3281.32541.
4
Vitamin D and depression: mechanisms, determination and application.维生素D与抑郁症：作用机制、测定方法及应用
Asia Pac J Clin Nutr. 2019;28(4):689-694. doi: 10.6133/apjcn.201912_28(4).0003.
5
Depression.抑郁。
Lancet. 2018 Nov 24;392(10161):2299-2312. doi: 10.1016/S0140-6736(18)31948-2. Epub 2018 Nov 2.
6
Association between vitamin D deficiency and antepartum and postpartum depression: a systematic review and meta-analysis of longitudinal studies.维生素D缺乏与产前及产后抑郁之间的关联：一项纵向研究的系统评价与荟萃分析
Arch Gynecol Obstet. 2018 Dec;298(6):1045-1059. doi: 10.1007/s00404-018-4902-6. Epub 2018 Sep 27.
7
High Dose Vitamin D Supplementation Is Associated With a Reduction in Depression Score Among Adolescent Girls: A Nine-Week Follow-Up Study.高剂量维生素D补充剂与青春期女孩抑郁评分降低相关：一项为期九周的随访研究。
J Diet Suppl. 2018 Mar 4;15(2):173-182. doi: 10.1080/19390211.2017.1334736. Epub 2017 Jul 31.
8
Vitamin D and depression.维生素D与抑郁症
J Affect Disord. 2017 Jan 15;208:56-61. doi: 10.1016/j.jad.2016.08.082. Epub 2016 Oct 11.
9
Serum brain-derived neurotrophic factor, glial-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 levels in children with attention-deficit/hyperactivity disorder.血清脑源性神经营养因子、胶质源性神经营养因子、神经生长因子和神经营养素-3 水平在注意缺陷/多动障碍儿童中的变化。
Eur Child Adolesc Psychiatry. 2017 Mar;26(3):355-363. doi: 10.1007/s00787-016-0898-2. Epub 2016 Aug 25.
10
A randomized controlled trial of vitamin D supplementation on perinatal depression: in Iranian pregnant mothers.维生素D补充剂对围产期抑郁症影响的随机对照试验：针对伊朗孕妇
BMC Pregnancy Childbirth. 2016 Aug 20;16:239. doi: 10.1186/s12884-016-1024-7.
Zotero 插件