Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy University of Reading, Reading RG6 6AP, UK.
Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait.
Nutrients. 2022 Apr 8;14(8):1548. doi: 10.3390/nu14081548.
Low serum vitamin D has been associated with an increased risk of neuropsychiatry disorders. This study aimed to examine the association between vitamin D deficiency and depression in adults aged 65 years and older. This cross-sectional study was conducted in seven primary healthcare centers across Kuwait (November 2020 to June 2021). The participants (n = 237) had their serum vitamin D 25-(OH)-D concentrations (analyzed by LC-MS) classified as sufficient, ≥75 nmol/L (30 ng/mL); insufficient, 50−75 nmol/L (20−30 ng/mL); or deficient, <50 nmol/L (20 ng/mL). Depressive symptoms were evaluated using the 15-Item Geriatric Depression Scale (15-item GDS). The mean serum 25-OH-D levels (nmol/L) in volunteers with normal, mild, moderate, and severe depression were 100.0 ± 31.7, 71.2 ± 38.6, 58.6 ± 30.1 and 49.0 ± 6.93, respectively (p < 0.001). The participants in the vitamin D sufficiency group were significantly less likely to exhibit depressive symptoms (88.2%) than patients with mild (36%) and moderate (21%) depression (p < 0.001). Ordinal logistic regression showed that vitamin D deficiency (OR = 19.7, 95% CI 5.60, 74.86, p < 0.001) and insufficiency (OR = 6.40, 95% CI 2.20, 19.91, p < 0.001) were associated with higher odds of having depressive symptoms. A low serum vitamin D level is a significant predictor of symptoms of depression among older individuals.
血清维生素 D 水平较低与神经精神疾病风险增加有关。本研究旨在探讨老年人维生素 D 缺乏与抑郁之间的关系。这项横断面研究在科威特的 7 个初级保健中心进行（2020 年 11 月至 2021 年 6 月）。参与者（n=237）的血清维生素 D 25-（OH）-D 浓度（通过 LC-MS 分析）被分类为充足，≥75 nmol/L（30ng/mL）；不足，50-75 nmol/L（20-30ng/mL）；或缺乏，<50 nmol/L（20ng/mL）。抑郁症状使用 15 项老年抑郁量表（15-item GDS）进行评估。在没有、轻度、中度和重度抑郁的志愿者中，血清 25-OH-D 水平（nmol/L）的平均值分别为 100.0±31.7、71.2±38.6、58.6±30.1 和 49.0±6.93（p<0.001）。维生素 D 充足组发生抑郁症状的可能性显著低于轻度抑郁（36%）和中度抑郁（21%）患者（p<0.001）。有序逻辑回归显示，维生素 D 缺乏（OR=19.7，95%CI 5.60，74.86，p<0.001）和不足（OR=6.40，95%CI 2.20，19.91，p<0.001）与发生抑郁症状的几率更高相关。血清维生素 D 水平低是老年人抑郁症状的一个重要预测指标。
