丝虫中的细菌沃尔巴克氏体，一种生物学的套娃系统：抗丝虫治疗的新趋势。

The bacteria Wolbachia in filariae, a biological Russian dolls' system: new trends in antifilarial treatments.

机构信息

INSERM, USM 307, Parasitologie comparée et Modèles expérimentaux, Muséum National d'Histoire Naturelle, 61, rue Buffon, CP52, Paris Cedex 05, France.

出版信息

Parasite. 2010 Jun;17(2):79-89. doi: 10.1051/parasite/2010172079.

DOI:10.1051/parasite/2010172079

PMID:20597434

Abstract

Filarial nematode species can host Wolbachia bacterial endosymbionts. To understand the symbiosis, a higher level of complexity should be considered, taking in account the tripartite association between Wolbachia, filariae and mammals. This overview article discusses the biology of Wolbachia in filariae, including their distribution and phylogeny, mechanisms of action, inflammatory consequences on mammal host and biological control implications for filariases. Potential directions for future research are also discussed.

摘要

丝虫线虫物种可以携带沃尔巴克氏体细菌共生体。为了理解这种共生关系，应该考虑更高的复杂性，将沃尔巴克氏体、丝虫和哺乳动物之间的三方关系考虑在内。本文综述了沃尔巴克氏体在丝虫中的生物学特性，包括其分布和系统发育、作用机制、对哺乳动物宿主的炎症后果以及对丝虫病的生物控制意义。还讨论了未来研究的潜在方向。