Department of Chemistry, One Shields Ave, University of California, Davis, California 95616, USA.
Org Lett. 2010 Aug 6;12(15):3324-7. doi: 10.1021/ol100929z.
An efficient, convergent synthesis of totarol by a diastereoselective epoxide/alkene/arene bicyclization is described. The reported synthesis enables the preparation of related diterpenes totaradiol and totarolone as well as previously unavailable derivatives that exhibit comparable inhibition of the bacterial cell division protein FtsZ.
描述了一种通过非对映选择性环氧化合物/烯烃/芳烃双环化反应高效、收敛合成托塔罗尔的方法。该报道的合成方法可制备相关的二萜托塔罗醇和托塔罗酮以及以前无法获得的衍生物,这些衍生物对细菌分裂蛋白 FtsZ 具有相当的抑制作用。