Laboratoire de Pharmacognosie de Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, U.M.R./C.N.R.S. 8638, 4, Avenue de l'Observatoire, 75006 Paris, France.
Nat Prod Rep. 2015 Feb;32(2):230-55. doi: 10.1039/c4np00077c.
The neodolastane diterpenoids comprise a group of 44 compounds including guanacastepenes, heptemerones, plicatilisins, radianspenes, 2,15-epoxy-5,13-dihydroxyneodolast-3-en-14-one and sphaerostanol. These fungal and marine natural products are characterized by a tricyclic neodolastane skeleton that consists of fused five-, seven- and six-membered rings. Their reported antibiotic activities against antibiotic-resistant bacteria together with strong antifungal and anticancer activities and their novel structures render these compounds interesting synthetic targets. The aim of this account is to summarise the progress in the isolation, characterisation and synthesis of these diterpenoids as well as to review their biogenetic origins and diverse biological activities since their discovery in 2000.
新多立烷二萜类化合物包括一组 44 种化合物，包括瓜纳卡斯特二萜烯、庚甲酮、普利卡辛、雷迪纳斯二萜烯、2,15-环氧-5,13-二羟基新多立烷-3-烯-14-酮和球甾醇。这些真菌和海洋天然产物的特点是具有三环新多立烷骨架，由融合的五、七和六元环组成。这些化合物具有抗耐药菌的抗生素活性、较强的抗真菌和抗癌活性以及新颖的结构，使其成为有趣的合成目标。本文旨在总结这些二萜类化合物的分离、鉴定和合成方面的进展，并综述其生物起源和多样化的生物活性，自 2000 年发现以来。
