Department of Neurology and Neurophysiology, Hannover Medical School, Carl-Neuberg Strasse 1, Hannover, Germany.
Int J Infect Dis. 2010 Sep;14 Suppl 3:e313-6. doi: 10.1016/j.ijid.2010.02.2257. Epub 2010 Jul 4.
We report the case of a 50-year-old female patient with non-active sarcoidosis and no kind of immunosuppression, admitted to our hospital because of increasing confusion and focal neurological deficits. Initially a tumor, herpes encephalitis, or neurosarcoidosis were suspected, but surprisingly biopsy revealed progressive multifocal leukoencephalopathy, additionally confirmed by JC-positive PCR in cerebrospinal fluid. Cases of sarcoidosis and progressive multifocal leukoencephalopathy have been reported before. This is the first case of a patient with no sign of active sarcoidosis and without immunosuppressive therapy who recovered spontaneously with a follow-up time of nearly 3 years.
我们报告了一例 50 岁女性非活动性结节病患者，无任何免疫抑制治疗，因进行性意识混乱和局灶性神经功能缺损而收入我院。最初怀疑为肿瘤、疱疹性脑炎或神经结节病，但令人惊讶的是，活检显示进展性多灶性脑白质病，此外，脑脊液中 JC 阳性 PCR 也证实了这一点。结节病和进展性多灶性脑白质病的病例以前也有报道。这是首例无活动性结节病迹象且无免疫抑制治疗的患者，随访近 3 年后自发恢复。
