Research Center for Environmental Risk, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
Toxicol Lett. 2010 Oct 5;198(2):93-9. doi: 10.1016/j.toxlet.2010.06.022. Epub 2010 Jul 3.
Chemical susceptibility is triggered by a large range of chemicals present both indoors and outdoors including pesticides, cleaning products, perfumes, scented products and cigarette smoke. Health risk after chemical exposure depends on age, sex, genetic factors, socioeconomic status, nutritional status, and environmental factors. Toluene is one of volatile organic chemicals that causes different sensitivity in individuals. Although neurotoxic and immunotoxic effects of toluene have been studied extensively, the underlying mechanism remains obscure. This review highlights the possible neuroimmune factors influencing toluene sensitivity and neurotoxicity in a mouse model.
化学敏感性是由室内和室外存在的大量化学物质引发的，包括杀虫剂、清洁产品、香水、香味产品和香烟烟雾。化学暴露后的健康风险取决于年龄、性别、遗传因素、社会经济地位、营养状况和环境因素。甲苯是一种挥发性有机化合物，会导致个体产生不同的敏感性。尽管甲苯的神经毒性和免疫毒性已经得到了广泛的研究，但潜在的机制仍然不清楚。本综述强调了可能影响甲苯敏感性和神经毒性的神经免疫因素在小鼠模型中的作用。
