Wang Yinjiao, Du Peng
Department of Radiology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China.
Biomed Rep. 2024 Sep 3;21(5):163. doi: 10.3892/br.2024.1851. eCollection 2024 Nov.
Organic solvents are a class of volatile, lipophilic substances that can easily enter the human body through skin and mucous membrane contact as well as air inhalation, and can lead to toxic encephalopathy (TE), especially after entering the lipid-rich nervous system. The present case reports a patient with acute organic solvent toxic encephalopathy (AOSTE), which may have been caused by occasional ink leakage from Xuzhou (Jiangsu, China). By summarizing the history the patient to exposure to organic solvents, clinical manifestations, radiology findings and relevant laboratory tests, we hypothesize that a history of ink exposure, brain magnetic resonance imaging findings and hippuric acid testing were indispensable factors in the diagnosis of AOSTE. After neurological treatment, the patient experienced notable improvement in symptoms. The present study reports on its clinical features, imaging features, treatment and follow-up, and review relevant literature to summarize its clinical experience, hoping to improve our understanding of AOSTE.
有机溶剂是一类挥发性亲脂性物质，可通过皮肤和黏膜接触以及吸入空气轻易进入人体，并可导致中毒性脑病（TE），尤其是在进入富含脂质的神经系统后。本病例报告了一名急性有机溶剂中毒性脑病（AOSTE）患者，可能是由中国江苏徐州的油墨偶然泄漏所致。通过总结患者接触有机溶剂的病史、临床表现、影像学检查结果及相关实验室检查，我们推测油墨接触史、脑磁共振成像结果及马尿酸检测是诊断AOSTE不可或缺的因素。经过神经治疗后，患者症状有明显改善。本研究报告了其临床特征、影像学特征、治疗及随访情况，并回顾相关文献以总结临床经验，希望能增进我们对AOSTE的认识。
