Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
Steroids. 2010 Dec;75(12):1005-10. doi: 10.1016/j.steroids.2010.06.012. Epub 2010 Jul 1.
Androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta were synthesized from 2alpha,3alpha,17beta-trihydroxy-5alpha-androstan-6-one after the protection of the 2alpha,3alpha-diols upon treatment with the corresponding alpha-azido acid and the subsequent deprotection of the diol grouping. Six new castasterone analogues were prepared. The biological activities were evaluated in two bioassays: a rice lamina inclination test and bean second internode bioassays. The activities of the new analogues differ in these two bioassays.
17β位带有α-叠氮酸酯基团的雄烷 brassinosteroid 类似物是由 2α,3α,17β-三羟基-5α-雄烷-6-酮合成的，该化合物是在用相应的α-叠氮酸处理后保护 2α,3α-二醇，然后脱保护二醇基团得到的。合成了 6 种新的 castasterone 类似物。在两种生物测定中评价了它们的生物活性：水稻叶片倾斜试验和菜豆第二节间生物测定。新类似物在这两种生物测定中的活性不同。
