Chodounská Hana, Pouzar Vladimír, Budesínský Milos, Slavíková Barbora, Kohout Ladislav
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic.
Steroids. 2004 Sep;69(10):605-12. doi: 10.1016/j.steroids.2004.04.007.
3alpha,17beta-Dihydroxy-3beta-methyl-5alpha-androstan-6-one (1) and 3beta,17beta-dihydroxy-3alpha-methyl-5alpha-androstan-6-one (13) were prepared by the reaction of methylmagnesium bromide with the 3-ketosteroids. Structures and configurations in position 3 were determined by NMR spectra. Substitution in the position 6 influences the ratio of the products.
通过溴化甲基镁与3-酮甾体的反应制备了3α,17β-二羟基-3β-甲基-5α-雄甾烷-6-酮（1）和3β,17β-二羟基-3α-甲基-5α-雄甾烷-6-酮（13）。3位的结构和构型通过核磁共振光谱确定。6位的取代影响产物的比例。
