Dipartimento di Morfologia Umana e Scienze Biomediche-Città Studi, Università degli Studi di Milano, Milan, Italy.
Int J Biochem Cell Biol. 2010 Oct;42(10):1590-3. doi: 10.1016/j.biocel.2010.06.015. Epub 2010 Jun 25.
Bone undergoes continuous remodeling under physiological and pathological conditions. Failure of the regulation of this process leads to several disorders involving bone erosion. This series of events is mainly based on the action of proteinases, particularly matrix metalloproteinases (MMPs). MMPs have been recently suggested as potential bone resorption markers which could be added to the commonly used ones, in order to predict outcome of disease processes and healing, and to monitor disease response to treatment. As for classical biochemical bone markers, MMPs are far from being applied in primary clinical diagnosis, but they could be promising in some cases for disease prognosis. MMPs as bone remodeling biomarkers could provide information that boosts our understanding of the prognosis, disease activity and pathogenesis of bone disorders. Clarifying the MMPs' role in bone remodeling and healing could potentially help predict disease progression and the effects of direct specific therapy.
在生理和病理条件下，骨骼会持续进行重塑。如果这个过程的调节失败，就会导致几种涉及骨质侵蚀的疾病。这一系列事件主要是蛋白酶，尤其是基质金属蛋白酶（MMPs）的作用。MMPs 最近被认为是潜在的骨吸收标志物，它们可以与常用的标志物一起使用，以预测疾病过程和愈合的结果，并监测疾病对治疗的反应。对于经典的生化骨标志物，MMPs 远未应用于初级临床诊断，但在某些情况下，它们对疾病预后可能有一定的预测价值。MMPs 作为骨重塑的生物标志物，可以提供有助于我们理解骨疾病预后、疾病活动和发病机制的信息。阐明 MMPs 在骨重塑和愈合中的作用，有可能帮助预测疾病进展和直接特定治疗的效果。
