Siebel Anna Maria, Basso da Silva Luciano
Biological Sciences Department, Centro Universitário Feevale, Novo Hamburgo, RS, Brazil.
Toxicol Ind Health. 2010 Oct;26(9):619-23. doi: 10.1177/0748233710375948. Epub 2010 Jul 2.
Some studies have shown increased DNA damage among car painters, but other professionals working in auto body and paint shops have not been extensively assessed. The aim of this study was to assess DNA damage in different types of auto body shop workers by measuring micronucleus (MN) levels in exfoliated buccal cells. The mean number of cells with MN per 2000 exfoliated buccal cells was analyzed in three groups of male workers: auto body repair technicians, painters, and office workers (control group). All participants answered a questionnaire inquiring about age, smoking habits, alcohol consumption, work practices, occupational exposure time, job activities, and use of protective equipment. The mean number of cells with MN was 3.50 ± 1.50 in auto body painters, 3.91 ± 2.10 in auto body repair technicians, and 0.80 ± 0.78 in office workers, with a significant difference between the control group and the two other groups (p = 0.0001). Age, occupational exposure time, use of protective masks, alcohol consumption, and smoking habit did not affect MN results. The findings indicate that technicians and painters working in auto body shops are at risk for genotoxic damage, while office workers seem to be protected.
一些研究表明，汽车喷漆工的DNA损伤有所增加，但在汽车车身和喷漆车间工作的其他专业人员尚未得到广泛评估。本研究的目的是通过测量脱落颊细胞中的微核（MN）水平，评估不同类型汽车车身车间工人的DNA损伤情况。在三组男性工人中分析了每2000个脱落颊细胞中含MN的细胞平均数：汽车车身修理技师、喷漆工和办公室职员（对照组）。所有参与者都回答了一份问卷，询问年龄、吸烟习惯、饮酒情况、工作方式、职业暴露时间、工作活动以及防护设备的使用情况。汽车车身喷漆工中含MN的细胞平均数为3.50±1.50，汽车车身修理技师为3.91±2.10，办公室职员为0.80±0.78，对照组与其他两组之间存在显著差异（p = 0.0001）。年龄、职业暴露时间、防护口罩的使用、饮酒情况和吸烟习惯均未影响MN结果。研究结果表明，在汽车车身车间工作的技师和喷漆工存在遗传毒性损伤风险，而办公室职员似乎受到了保护。
