Department of Internal Medicine, Gulhane Military Medical Academy, Ankara, Turkey.
Endokrynol Pol. 2010 May-Jun;61(3):275-9.
The aim of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on glycaemic control, atherosclerosis, inflammatory markers, and other clinical and laboratory parameters in patients undergoing systemic HBOT for diabetic foot ulcerations.
Twenty-eight patients with Wagner grade 2-4 diabetic foot ulcerations were included. All patients were given 100% oxygen at 2.4 absolute atmosphere (ATA) for about 105 minutes, five times a week for a total of 30 sessions. Fasting blood glucose (FBG), haemoglobin A1c (HbA1c), homeostasis model measurement-insulin resistance (HOMA-IR), high sensitivity C-reactive protein (hs-CRP), uric acid, mean platelet volume (MPV), complete blood count, and lipid profile were tested.
Upon completion of treatment, a statistically significant improvement was observed in the mean values of all assessed parameters.
HBOT was shown to have beneficial effects on atherosclerosis and glycaemic control in diabetic patients. Further large-scale randomized studies are needed to study the systemic effects of HBOT.
本研究旨在探讨高压氧治疗（HBOT）对 2-4 期糖尿病足溃疡患者血糖控制、动脉粥样硬化、炎症标志物及其他临床和实验室参数的影响。
共纳入 28 例 Wagner 2-4 级糖尿病足溃疡患者。所有患者均接受 100%氧气 2.4 个绝对大气压（ATA）治疗，每次约 105 分钟，每周 5 次，共 30 次。检测空腹血糖（FBG）、糖化血红蛋白（HbA1c）、稳态模型评估胰岛素抵抗（HOMA-IR）、高敏 C 反应蛋白（hs-CRP）、尿酸、平均血小板体积（MPV）、全血细胞计数和血脂谱。
治疗完成后，所有评估参数的平均值均有统计学意义的改善。
HBOT 对糖尿病患者的动脉粥样硬化和血糖控制有有益影响。需要进一步开展大规模随机研究来研究 HBOT 的全身作用。
