Giri D K, Jayaraman S, Neelaram G S, Jayashankar R, Talwar G P
National Institute of Immunology, New Delhi, India.
Exp Mol Pathol. 1991 Jun;54(3):255-64. doi: 10.1016/0014-4800(91)90035-v.
An active immunization study using semisynthetic anti-luteinizing hormone releasing hormone (LHRH) vaccine was undertaken in adult male bonnet monkeys (Macaca radiata). Four male bonnet monkeys were immunized with LHRH-DT vaccine (100 micrograms/monkey). When the elevation of serum anti-LHRH titers reached an effective concentration, a remarkable decrease in serum testosterone level was observed. The sperm counts at 12 and 20 weeks following immunization in all immunized monkeys were reduced markedly. One representative animal with high antibody titer along with an age-matched control animal was sacrificed 20 weeks following primary immunization. The prostate weight of the immunized monkey was reduced to one-third (0.027) of the control (0.085). A reduction was also observed in other reproductive organs. Remaining animals are being studied for a reversible effect of immunization. Thus the study demonstrates that the size of the prostate can be reduced significantly by inhibition of hypothalamic-pituitary-testicular axis using this anti-LHRH vaccine.
在成年雄性帽猴（食蟹猴）身上进行了一项使用半合成抗促黄体生成素释放激素（LHRH）疫苗的主动免疫研究。四只雄性帽猴用LHRH-DT疫苗（100微克/只猴）进行免疫。当血清抗LHRH滴度升高达到有效浓度时，观察到血清睾酮水平显著下降。所有免疫猴在免疫后12周和20周时的精子计数明显减少。在初次免疫20周后，处死了一只具有高抗体滴度的代表性动物以及一只年龄匹配的对照动物。免疫猴的前列腺重量降至对照（0.085）的三分之一（0.027）。在其他生殖器官中也观察到了重量减轻。其余动物正在研究免疫的可逆作用。因此，该研究表明，使用这种抗LHRH疫苗抑制下丘脑-垂体-睾丸轴可显著减小前列腺的大小。
