Jagannadha Rao A, Chakraborti R, Kotagi S G, Ravindranath N, Moudgal N R
J Steroid Biochem. 1985 Nov;23(5B):807-9. doi: 10.1016/s0022-4731(85)80019-4.
A few analogues of LHRH have been tested in the adult bonnet monkeys using change in serum testosterone following LHRH injection as a parameter of response to LHRH. Of the four analogues tested in male monkeys, Buserelin was found to be the most potent one in increasing serum testosterone levels. Injection of the LHRH antagonist at 1600 h resulted in the abolition of the characteristic nocturnal surge of testosterone observed in adult bonnet monkeys maintained under regulated light conditions. Following administration of LHRH a/s during early pregnancy, serum chorionic gonadotropin levels decreased though the course of pregnancy was not affected. These results suggest that bonnet monkey can be successfully employed to test LHRH analogues.
已在成年冠毛猕猴中对几种促黄体生成素释放激素（LHRH）类似物进行了测试，以注射LHRH后血清睾酮的变化作为对LHRH反应的参数。在雄性猕猴中测试的四种类似物中，发现布舍瑞林在提高血清睾酮水平方面最为有效。在16:00注射LHRH拮抗剂导致在受调控光照条件下饲养的成年冠毛猕猴中观察到的典型夜间睾酮激增消失。在妊娠早期给予LHRH a/s后，血清绒毛膜促性腺激素水平下降，不过妊娠过程未受影响。这些结果表明，冠毛猕猴可成功用于测试LHRH类似物。
