哥斯达黎加、尼加拉瓜、洪都拉斯和多米尼加共和国的轮状病毒基因型。

Rotavirus genotypes in Costa Rica, Nicaragua, Honduras and the Dominican Republic.

机构信息

Instituto de Investigaciones Científicas, INDICASAT, Panamá City, Panama.

出版信息

Intervirology. 2010;53(6):390-3. doi: 10.1159/000317288. Epub 2010 Jul 2.

PMID:20606460

Abstract

In this study, 574 stool samples from children with gastroenteritis were obtained from different hospitals in Costa Rica, Honduras, Nicaragua and the Dominican Republic during 2005-2006. Diarrhea stool samples were analyzed for rotavirus by ELISA and typed by the RT-PCR-based method. Unusual strains were detected: G1P6, G2P8, G3P6, G9P4 and mixed infections. Recent studies have indicated that unusual human rotavirus strains are emerging as global strains, which has important implications for effective vaccine development. In this context, the next generation of rotavirus vaccines will need to provide adequate protection against diseases caused not only by mixed infections, but also by unusual G/P combinations.

摘要

本研究于 2005-2006 年期间，从哥斯达黎加、洪都拉斯、尼加拉瓜和多米尼加共和国的不同医院收集了 574 份患有肠胃炎的儿童粪便样本。通过 ELISA 法对腹泻粪便样本进行轮状病毒分析，并通过基于 RT-PCR 的方法进行分型。检测到了不常见的菌株：G1P6、G2P8、G3P6、G9P4 和混合感染。最近的研究表明，不常见的人类轮状病毒株正在成为全球性流行株，这对有效疫苗的开发具有重要意义。在这种情况下，下一代轮状病毒疫苗不仅需要对混合感染引起的疾病提供充分的保护，还需要对不常见的 G/P 组合引起的疾病提供充分的保护。