韩国首尔地区与急性肠胃炎相关的轮状病毒基因型。

Genotypes of rotavirus associated with acute gastroenteritis in Seoul, Korea.

机构信息

Virus Team, Seoul Metropolitan Government Research Institute of Public Health and Environment, 202-3 Yangjae-Dong, Seocho-Gu, Seoul 137-734, Korea.

出版信息

Microbiol Immunol. 2011 Sep;55(9):641-4. doi: 10.1111/j.1348-0421.2011.00366.x.

DOI:10.1111/j.1348-0421.2011.00366.x

PMID:21752085

Abstract

Acute viral gastroenteritis is one of the most common infectious diseases in infants and young children. Rotavirus is mainly important in childhood. The present study determined the detection rate, seasonality and G and P genotypes of rotaviruses in children hospitalized for acute gastroenteritis in Seoul, Korea in 2009. A total of 1,423 stool specimens were screened by ELISA for the presence of rotavirus antigens and the rotavirus-positive stools genotyped by RT-PCR. The G genotype was determined for 90% of samples (242/269) and the P genotype for 93.3% (251/269). During the study, 25 G-P combinations were detected with G1P[8] in 38.3% (n= 103) and G4P[6] in 5.9% (n= 16) cases. These data provided information on rotavirus in patients with acute gastroenteritis in Seoul, Korea and provided baseline data to motivate for the implementation of control measures for rotavirus disease.

摘要

急性病毒性胃肠炎是婴幼儿最常见的传染病之一。轮状病毒在儿童中尤为重要。本研究旨在确定 2009 年韩国首尔因急性胃肠炎住院的儿童中轮状病毒的检出率、季节性和 G、P 基因型。通过 ELISA 对 1423 份粪便标本进行轮状病毒抗原检测，对轮状病毒阳性粪便进行 RT-PCR 基因分型。对 90%的样本（242/269）进行 G 基因型检测，对 93.3%的样本（251/269）进行 P 基因型检测。研究期间，共检测到 25 种 G-P 组合，其中 G1P[8]占 38.3%（103 例），G4P[6]占 5.9%（16 例）。这些数据为韩国首尔地区急性胃肠炎患者的轮状病毒提供了信息，并为实施轮状病毒病的控制措施提供了基线数据。