Bae Sang Hoon, Kim Dong Hyun, Bae Young Seok, Lee Kwang Jae, Kim Dong Wan, Yoon Jeoung Bin, Hong Joon Ho, Kim Sang Hyun
Department of Internal Medicine, Good Samsun Hospital, Korea.
Korean J Hepatol. 2010 Jun;16(2):182-6. doi: 10.3350/kjhep.2010.16.2.182.
Toxic hepatitis has been reported as a major cause of acute hepatitis, but its potential induction by herbal remedies and/or health foods is usually neglected. We experienced a case of toxic hepatitis associated with Polygoni multiflori, a Chinese herb commonly known as Ho-Shou-Wu. A 54-year-old woman consumed Ho-Shou-Wu for 1 month, after which she experienced fatigue and overall weakness. A diagnosis of toxic hepatitis was made based on her clinical history, the findings for viral markers and other laboratory data, and ultrasonography. Her condition improved considerably after she stopped taking Ho-Shou-Wu. However, she resumed taking Ho-Shou-Wu immediately after discharge from hospital, which aggravated her symptoms and liver function. She was immediately readmitted and stopped taking Ho-Shou-Wu. Her relapse into hepatitis immediate after resuming consumption of the herb is strongly indicative of the validity of Koch's postulate in this case.
中毒性肝炎已被报道为急性肝炎的主要病因，但其由草药和/或健康食品引发的可能性通常被忽视。我们遇到了一例与何首乌（一种俗称“何首乌”的中药）相关的中毒性肝炎病例。一名54岁女性服用何首乌1个月后，出现疲劳和全身乏力。根据她的临床病史、病毒标志物检查结果及其他实验室数据以及超声检查结果，诊断为中毒性肝炎。她停止服用何首乌后病情明显好转。然而，出院后她立即又开始服用何首乌，这使她的症状和肝功能恶化。她再次入院并停止服用何首乌。再次服用该草药后肝炎立即复发，这有力地表明在此病例中柯赫法则的有效性。
