Athens University, Goudi, Greece.
Biogerontology. 2010 Dec;11(6):725-9. doi: 10.1007/s10522-010-9293-4. Epub 2010 Jul 6.
Ageing still remains a conundrum on the cellular and molecular level, while environmental factors and interactions further increase the complexity of the ageing process. On the other hand is cancer, for which 20 years ago, it was proposed by Trichopoulos that it might have intrauterine origin. We herein discuss the idea that parameters such as the influence of insulin-like growth factor (IGF) signalling, of hormones and of the number of stem cells, as well as the effect of foetal and early life nutrition on ageing may also commence in utero and we provide epidemiological and biological data to advocate for this hypothesis. Finally, we analyse the public health implication of this hypothesis based on the World Health Organization (WHO) report that the burden of diseases, including ageing, may be due to impaired foetal development.
衰老是一个在细胞和分子水平上的难题，而环境因素和相互作用进一步增加了衰老过程的复杂性。另一方面是癌症，20 年前，Trichopoulos 提出它可能具有宫内起源。本文讨论了这样一种观点，即诸如胰岛素样生长因子（IGF）信号、激素和干细胞数量的影响，以及胎儿和生命早期营养对衰老的影响等参数也可能在子宫内开始，并提供流行病学和生物学数据来支持这一假设。最后，我们根据世界卫生组织（WHO）的报告，即包括衰老在内的疾病负担可能是由于胎儿发育受损，分析了这一假设对公共卫生的影响。
