Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.
Org Lett. 2010 Aug 6;12(15):3304-7. doi: 10.1021/ol101286a.
An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks, which are encircled by cucurbit[6]uril or alpha-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles.
本文从原理层面展示了一种机械介孔硅纳米粒子的设计和制造方法。该方法依赖于纳米体系内的二硫键的还原裂解，其中，表面结合的轮烷的侧臂中含有二硫键，这些二硫键被葫芦脲或α-环糊精环包围，直到进行还原化学处理，导致轮烷的侧臂断裂，从而使纳米粒子内部的货物释放出来。
