Vivero-Escoto Juan L, Huang Yu-Tzu
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Int J Mol Sci. 2011;12(6):3888-927. doi: 10.3390/ijms12063888. Epub 2011 Jun 10.
Nanotechnology offers outstanding potential for future biomedical applications. In particular, due to their unique characteristics, hybrid nanomaterials have recently been investigated as promising platforms for imaging and therapeutic applications. This class of nanoparticles can not only retain valuable features of both inorganic and organic moieties, but also provides the ability to systematically modify the properties of the hybrid material through the combination of functional elements. Moreover, the conjugation of targeting moieties on the surface of these nanomaterials gives them specific targeted imaging and therapeutic properties. In this review, we summarize the recent reports in the synthesis of hybrid nanomaterials and their applications in biomedical areas. Their applications as imaging and therapeutic agents in vivo will be highlighted.
纳米技术在未来生物医学应用中具有巨大潜力。特别是，由于其独特的特性，杂化纳米材料最近已被研究作为成像和治疗应用的有前途的平台。这类纳米颗粒不仅可以保留无机和有机部分的宝贵特性，还能够通过功能元素的组合系统地改变杂化材料的性质。此外，在这些纳米材料表面连接靶向部分赋予它们特定的靶向成像和治疗特性。在本综述中，我们总结了杂化纳米材料合成及其在生物医学领域应用的最新报道。将重点介绍它们在体内作为成像和治疗剂的应用。
