Guardado-Alvarez Tania M, Devi Lekshmi Sudha, Vabre Jean-Marie, Pecorelli Travis A, Schwartz Benjamin J, Durand Jean-Olivier, Mongin Olivier, Blanchard-Desce Mireille, Zink Jeffrey I
Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, California 90095-1569, USA.
Nanoscale. 2014 May 7;6(9):4652-8. doi: 10.1039/c3nr06155h.
We report the design and synthesis of a nano-container consisting of mesoporous silica nanoparticles with the pore openings covered by "snap-top" caps that are opened by near-IR light. A photo transducer molecule that is a reducing agent in an excited electronic state is covalently attached to the system. Near IR two-photon excitation causes inter-molecular electron transfer that reduces a disulfide bond holding the cap in place, thus allowing the cargo molecules to escape. We describe the operation of the "snap-top" release mechanism by both one- and two-photon activation. This system presents a proof of concept of a near-IR photoredox-induced nanoparticle delivery system that may lead to a new type of photodynamic drug release therapy.
我们报道了一种纳米容器的设计与合成，该纳米容器由介孔二氧化硅纳米颗粒组成，其孔口被“卡扣式”帽覆盖，这些帽可被近红外光打开。一种在激发电子态下作为还原剂的光转换分子共价连接到该系统。近红外双光子激发导致分子间电子转移，从而还原固定帽的二硫键，进而使货物分子得以释放。我们通过单光子和双光子激活描述了“卡扣式”释放机制的运作。该系统展示了一种近红外光氧化还原诱导的纳米颗粒递送系统的概念验证，这可能会带来一种新型的光动力药物释放疗法。
