Miller R R, Young J T, Kociba R J, Keyes D G, Bodner K M, Calhoun L L, Ayres J A
Drug Chem Toxicol. 1985;8(1-2):1-42. doi: 10.3109/01480548509011632.
Male and female Fischer 344 rats and B6C3F1 mice were exposed to 0, 25 or 75 ppm (0, 0.10 or 0.31 mg/l) ethyl acrylate vapors, 6 hours per day, 5 days per week, for a total of 27 months. Additional rats and mice were exposed to 225 ppm (0.92 mg/l) for 6 months and then held for 21 additional months post-exposure. Histopathologic changes in olfactory portions of the nasal mucosa were present in animals in all of these three exposure groups. These microscopic exposure-related changes were concentration-dependent, primarily in terms of distribution of the lesions within the nasal cavity. Generally those areas of the nasal mucosa normally lined by olfactory epithelium were altered, while the regions lined by respiratory epithelium were relatively unaffected. There was no indication of an oncogenic response in any organ or tissue in either rats or mice. A follow-up study in which Fischer 344 rats and B6C3F1 mice were exposed to 5 ppm (0.02 mg/l) for 24-months revealed no treatment-related changes in the nasal mucosa.
将雄性和雌性Fischer 344大鼠以及B6C3F1小鼠暴露于0、25或75 ppm（0、0.10或0.31 mg/l）的丙烯酸乙酯蒸气中，每天6小时，每周5天，共27个月。另外的大鼠和小鼠暴露于225 ppm（0.92 mg/l）的蒸气中6个月，然后在暴露后再饲养21个月。在所有这三个暴露组的动物中，鼻腔黏膜嗅觉部分均出现了组织病理学变化。这些与暴露相关的微观变化具有浓度依赖性，主要体现在鼻腔内病变的分布方面。一般来说，鼻腔黏膜中正常由嗅觉上皮覆盖的区域发生了改变，而由呼吸上皮覆盖的区域相对未受影响。在大鼠或小鼠的任何器官或组织中均未显示出致癌反应。一项后续研究中，将Fischer 344大鼠和B6C3F1小鼠暴露于5 ppm（0.02 mg/l）的蒸气中24个月，结果显示鼻腔黏膜未出现与处理相关的变化。
