[Tolerance of ibuprofen. Controlled drug monitoring for the detection of rare side effects].

In an observational study, 6,299 patients suffering from arthrosis and other rheumatic diseases were treated by 1,258 physicians with coated tablets containing 400 mg or 600 mg ibuprofen (Ibuprofen Klinge 400/600) with a view to establish tolerance and the incidence of rare side effects. The data of a random sample of 500 patients revealed, depending upon the nature of the disease presenting, good to very good improvement of pain, swelling and impaired mobility. Only 3% of the patients reported side effects, 0.3% of which were allergic in nature. Only 0.8% of the patients terminated treatment. The care-providing physicians assessed the results as very good or good in 93.3% for efficacy, and 96.8% for tolerance.