Division of Genetics and Population Health, Queensland Institute of Medical Research, Herston, Brisbane, Queensland, Australia.
Dev Growth Differ. 2010 Aug;52(6):483-91. doi: 10.1111/j.1440-169X.2010.01185.x.
A single fertilized egg is programmed to differentiate into a multitude of distinct cell types that comprise a multicellular organism. Epigenetic mechanisms such as DNA methylation and histone modifications are intricately involved in regulating developmental potential and cellular identity by establishing permissive or repressive chromatin states that are mitotically heritable. Here, we review the dynamics of major epigenetic marks during early mammalian development, and explore the question of whether DNA methylation and chromatin modifications enable or enforce changes that lead to the first cell fate decision.
一个受精卵被编程分化为多种不同的细胞类型，这些细胞类型构成了一个多细胞生物体。表观遗传机制，如 DNA 甲基化和组蛋白修饰，通过建立有丝分裂可遗传的允许或抑制染色质状态，在调节发育潜能和细胞身份方面起着复杂的作用。在这里，我们回顾了早期哺乳动物发育过程中主要表观遗传标记的动态变化，并探讨了 DNA 甲基化和染色质修饰是否能够或强制导致第一个细胞命运决定的变化。
