与老年慢性阻塞性肺疾病患者体重指数相关的临床和炎症因素。
Clinical and inflammatory factors associated with body mass index in elderly patients with chronic obstructive pulmonary disease.
机构信息
Department of Rehabilitation Medicine, Kinki University School of Medicine, Osaka, Japan.
出版信息
Geriatr Gerontol Int. 2011 Jan;11(1):32-8. doi: 10.1111/j.1447-0594.2010.00629.x.
AIM
Body mass index (BMI) is closely associated with mortality in chronic obstructive pulmonary disease (COPD). Systemic inflammation has been suggested as one of the mechanisms of malnutrition in COPD. This study investigated the relationships of clinical variables and inflammatory biomarkers with BMI in COPD in an aging population.
METHODS
Baseline levels of serum biomarkers were determined for 69 patients with stable male COPD. Multivariate logistic regression was used to evaluate associations between clinical variables, including emphysema scores, and biomarkers with BMI.
RESULTS
Twenty eight patients were categorized as low BMI (<20 kg/m2). BMI was inversely correlated with serum α1-antitrypsin (α1-AT) concentration and emphysema scores, and was positively correlated with forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). Multivariate logistic regression analysis showed that α1-AT was independently associated with BMI.
CONCLUSION
Low BMI was associated with the severity of emphysema and systemic inflammation reflected by elevated α1-AT level.
目的
体重指数（BMI）与慢性阻塞性肺疾病（COPD）的死亡率密切相关。全身炎症被认为是 COPD 患者营养不良的机制之一。本研究旨在探讨老年 COPD 患者中临床变量和炎症生物标志物与 BMI 的关系。
方法
对 69 例稳定期男性 COPD 患者的血清生物标志物水平进行了基线检测。采用多元逻辑回归分析评估了临床变量（包括肺气肿评分）和生物标志物与 BMI 之间的相关性。
结果
28 例患者 BMI ＜20kg/m2。BMI 与血清α1-抗胰蛋白酶（α1-AT）浓度和肺气肿评分呈负相关，与用力肺活量（FVC）和 1 秒用力呼气量（FEV1）呈正相关。多元逻辑回归分析显示，α1-AT 与 BMI 独立相关。
结论
低 BMI 与肺气肿严重程度和全身性炎症有关，全身性炎症反映在 α1-AT 水平升高。
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