Young M R, Okada F, Tada M, Hosokawa M, Kobayashi H
Department of Research Services, Hines V.A. Hospital, Ill.
Invasion Metastasis. 1991;11(1):48-57.
Secretion of prostaglandin E2 (PGE2) by cloned variants of QR fibrosarcoma or of Lewis lung carcinoma (LLC) did not correspond with their in vivo aggressive behavior. However, aggressiveness may be influenced by tumor responsiveness to PGE2. Each of the metastatic LLC or progressor QRpP variants was more motile in an in vitro migration model than were either the nonmetastatic LLC or regressor QR variants. One of the two tested progressor QR variants and all of the metastatic LLC variants were also more responsive to PGE2 in their in vitro migration through a membrane than were either regressor QR or nonmetastatic LLC variants. Thus, responsiveness to PGE2 by tumors may regulate the degree of tumor aggressiveness in vivo.
QR纤维肉瘤或Lewis肺癌（LLC）的克隆变体分泌前列腺素E2（PGE2）的情况与其体内侵袭性行为并不相符。然而，侵袭性可能受肿瘤对PGE2反应性的影响。在体外迁移模型中，转移性LLC变体或进展性QRpP变体中的每一个都比非转移性LLC变体或消退性QR变体更具运动性。在通过膜的体外迁移过程中，两个测试的进展性QR变体之一以及所有转移性LLC变体对PGE2的反应也比消退性QR变体或非转移性LLC变体更强。因此，肿瘤对PGE2的反应性可能在体内调节肿瘤侵袭的程度。
