Cunningham C E, Siegel L S, Offord D R
Chedoke-McMaster Hospitals, Hamilton, Ontario, Canada.
J Child Psychol Psychiatry. 1991 Mar;32(3):439-52. doi: 10.1111/j.1469-7610.1991.tb00322.x.
To examine the social effects of methylphenidate, groups of 15 attention-deficit disordered boys with (ADD) and 15 ADD boys without conduct problems (ADD/CP) were paired with normal peers. ADD and ADD/CP children showed a different pattern of responses to methylphenidate. While on task behavior in ADD/CP dyads increased at 0.15 mg/kg doses, increases in ADD dyads were not observed until doses reached 0.50 mg/kg. Although controlling interaction in ADD children decreased at 0.15 mg/kg, the controlling behavior of ADD/CP children did not decline at either dose. Peers of both ADD and ADD/CP children showed reciprocal declines in controlling behavior. In both free play and cooperative task situations, 0.15 mg/kg increased social interaction in ADD boys and decreased social interaction in ADD/CP boys.
为研究哌甲酯的社会效应，将15名患有注意力缺陷障碍（ADD）且有品行问题的男孩和15名患有注意力缺陷障碍但无品行问题（ADD/CP）的男孩分别与正常同龄人配对。ADD组和ADD/CP组儿童对哌甲酯表现出不同的反应模式。在ADD/CP组中，剂量为0.15mg/kg时，任务相关行为增加，而ADD组直到剂量达到0.50mg/kg时任务相关行为才增加。虽然ADD儿童的控制互动在剂量为0.15mg/kg时减少，但ADD/CP儿童的控制行为在这两个剂量下均未下降。ADD组和ADD/CP组儿童的同龄人在控制行为上都出现了相应的下降。在自由玩耍和合作任务情境中，0.15mg/kg的剂量增加了ADD男孩的社交互动，减少了ADD/CP男孩的社交互动。
