Department of Internal Medicine, Division of Gastroenterology, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.
World J Gastroenterol. 2010 Jul 14;16(26):3287-91. doi: 10.3748/wjg.v16.i26.3287.
To assess the tolerability and safety of same-day tandem procedures, endoscopic ultrasound (EUS) followed by endoscopic retrograde cholangiopancreatography (ERCP) under conscious sedation.
A retrospective review was conducted at Loma Linda University Medical Center, a tertiary-care center. All 54 patients who underwent EUS followed by ERCP (group A) from 2004 to 2006 were included in the study. A second group of 56 patients who underwent EUS only (group B), and a third group of 53 patients who underwent ERCP only (group C) during the same time period were selected consecutively as control groups for comparison.
Conscious sedation was used in 96% of patients in group A. Mean dosages of meperidine and midazolam used in group A were significantly higher than in group B or C. Mean recovery time in group A was not statistically longer than in group B or C. There was no significant difference in the incidence of sedation-related and procedural-related complications.
Tandem EUS/ERCP procedure can be safely performed under conscious sedation with minimal adverse events. Combined procedures, however, are associated with higher dosages of sedatives, and slightly longer recovery time.
评估在清醒镇静下同日进行内镜超声（EUS）联合内镜逆行胰胆管造影术（ERCP）的耐受性和安全性。
该研究在三级医疗中心洛马林达大学医学中心进行回顾性分析。纳入了 2004 年至 2006 年间接受 EUS 联合 ERCP（A 组）的 54 例患者。同期还选择了 56 例仅接受 EUS（B 组）和 53 例仅接受 ERCP（C 组）的患者作为对照组进行比较。
A 组 96%的患者接受了清醒镇静。A 组中哌替啶和咪达唑仑的平均剂量明显高于 B 组和 C 组。A 组的平均恢复时间与 B 组和 C 组无统计学差异。镇静相关和操作相关并发症的发生率无显著差异。
在清醒镇静下进行 EUS/ERCP 联合操作是安全的，不良事件发生率低。然而，联合操作与镇静剂剂量更高、恢复时间略长有关。
