Pereira Cláudio M, Lopes Ana Paula M, Meneghini Alexandre J, Silva Geisa B L, Monteiro Mariana C, Botelho Tessa de L
Faculdade de Odontologia da Universidade Paulista, campus Flamboyant Patologia Oral Diagnóstico Oral Rodovia BR, 153, Km 503, Fazenda Botafogo - CEP: 74845-090 Goiania/GO - Brazil.
Malays J Pathol. 2010 Jun;32(1):59-64.
Burkitt's lymphoma is not an uncommon malignancy in the paediatric population. It is a high-grade non-Hodgkin B-cell lymphoma which may present as endemic, sporadic and human immunodeficiency-associated subtypes. The African, or endemic, variant usually involves the maxilla and other facial bones while head and neck manifestations in sporadic Burkitt's lymphoma are rare. We described a case of oral Burkitt's lymphoma involving the right jaw in a 4-year-old boy. The patient presented with a rapidly-enlarging swelling of one month duration, toothache-like pain and radiographical appearance of 'floating teeth' in the right mandible. Incisional biopsy revealed small round tumour cells with scarce cytoplasm and multiple small nuclei interspersed by phagocytic macrophages. The tumour cells were immunopositivity for CD20 and CD10, expressed weak positivity for CD3, negative for CD5 and showed > 90% positivity for Ki-67. Tumour remission was achieved with six cycles of chemotherapy with the CHOP regime.
伯基特淋巴瘤在儿科人群中并非罕见的恶性肿瘤。它是一种高度侵袭性的非霍奇金B细胞淋巴瘤，可表现为地方性、散发性和与人类免疫缺陷相关的亚型。非洲型或地方性变种通常累及上颌骨和其他面部骨骼，而散发性伯基特淋巴瘤的头颈部表现罕见。我们描述了一例4岁男孩右颌骨发生的口腔伯基特淋巴瘤病例。该患者出现持续一个月的迅速增大的肿胀、牙痛样疼痛以及右下颌骨“浮牙”的影像学表现。切开活检显示小圆形肿瘤细胞，胞质稀少，多个小核散在分布于吞噬性巨噬细胞之间。肿瘤细胞对CD20和CD10呈免疫阳性，对CD3呈弱阳性，对CD5呈阴性，对Ki-67呈>90%阳性。采用CHOP方案进行六个周期的化疗后实现了肿瘤缓解。
