Population Medicine, University of Guelph, Guelph, Ontario, Canada.
J Food Prot. 2010 Jul;73(7):1317-24. doi: 10.4315/0362-028x-73.7.1317.
Campylobacter is an important enteric pathogen of humans and can cause diarrhea, fever, and abdominal pain. Campylobacter infections have frequently been associated with the handling and consumption of raw and undercooked poultry. Antimicrobial resistance among Campylobacter strains is of concern in the treatment of campylobacteriosis in vulnerable populations. A 2-year multidisciplinary study was conducted in the Perth and Wellington-Dufferin-Guelph public health units in Ontario, Canada, to investigate the prevalence and antimicrobial resistance of Campylobacter spp. in retail chicken. Retail chicken samples were collected from randomly selected stores in these health units. Resulting Campylobacter isolates were tested for susceptibility to amoxicillin-clavulanic acid (AMC), ampicillin (AMP), chloramphenicol (CHL), ciprofloxacin (CIP), clindamycin (CLI), erythromycin (ERY), gentamicin (GEN), nalidixic acid (NAL), tetracycline (TCY), and trimethoprim-sulfamethoxazole (SXT) using the E test. The prevalence of Campylobacter in 1,256 retail chicken samples was 59.6%. Of these positive samples, 9% contained Campylobacter coli, 1% contained Campylobacter lari, and 90% contained Campylobacter jejuni. Of the chicken isolates that were resistant to one or more antimicrobial agents, 301 isolates (40%) were resistant to one agent, 374 (50%) were resistant to two, 39 (5%) were resistant to three, 20 (3%) were resistant to four, and 6 (1%) were resistant to five. Nine isolates (1%) were susceptible to all antimicrobial agents tested. All isolates were susceptible to AMC, CHL, and GEN. Less than 10% of isolates were resistant to NAL, CIP, CLI, ERY, and AMP. Resistance to TCY was common (56%). No isolates had a resistance pattern that included all three antimicrobials important in the treatment of human campylobacteriosis (CIP, ERY, and TCY); however, 24 isolates (3.2%) were resistant to at least two of these antimicrobials.
空肠弯曲菌是人类重要的肠道病原体，可引起腹泻、发热和腹痛。空肠弯曲菌感染常与生的和未煮熟的家禽的处理和食用有关。在脆弱人群中治疗弯曲菌病时，弯曲菌菌株的抗生素耐药性令人关注。在加拿大安大略省的珀斯和惠灵顿-杜弗林-格伦菲尔德公共卫生部门进行了为期 2 年的多学科研究，以调查零售鸡肉中空肠弯曲菌的流行情况和抗生素耐药性。从这些卫生部门的随机选择的商店中采集零售鸡肉样本。分离出的弯曲菌分离株用 E 试验检测对阿莫西林-克拉维酸（AMC）、氨苄西林（AMP）、氯霉素（CHL）、环丙沙星（CIP）、克林霉素（CLI）、红霉素（ERY）、庆大霉素（GEN）、萘啶酸（NAL）、四环素（TCY）和磺胺甲恶唑-甲氧苄啶（SXT）的敏感性。在 1256 份零售鸡肉样本中，空肠弯曲菌的流行率为 59.6%。在这些阳性样本中，9%含有大肠弯曲菌，1%含有拉里弯曲菌，90%含有空肠弯曲菌。在对一种或多种抗菌药物耐药的鸡分离株中，301 株（40%）对一种药物耐药，374 株（50%）对两种药物耐药，39 株（5%）对三种药物耐药，20 株（3%）对四种药物耐药，6 株（1%）对五种药物耐药。9 株（1%）对所有测试的抗菌药物均敏感。所有分离株均对 AMC、CHL 和 GEN 敏感。不到 10%的分离株对 NAL、CIP、CLI、ERY 和 AMP 耐药。TCY 的耐药性很常见（56%）。没有分离株具有包括治疗人类弯曲菌病的三种重要抗生素（CIP、ERY 和 TCY）在内的所有耐药模式；然而，24 株（3.2%）对至少两种这些抗生素耐药。
