Firrincieli D, Boissan M, Chignard N
UMR_S 938, centre de recherche Saint-Antoine, UPMC université Paris 06, 27 rue de Chaligny, Paris, France.
Gastroenterol Clin Biol. 2010 Oct;34(10):523-8. doi: 10.1016/j.gcb.2010.04.017. Epub 2010 Jul 7.
Epithelial-mesenchymal transition (EMT) is a physiological process occurring in the embryo. In adult organism, EMT could be involved in disease development. In the liver, the possibility that EMT of liver epithelial cells participate to liver fibrosis is increasingly discussed. Furthermore, the involvement of hepatocyte EMT to liver cancer biology has also been documented over the past few years. In this review, we will first describe how EMT participates to embryological development. We will then discuss the involvement of hepatocytes and biliary epithelial cells in liver fibrosis. Finally, we will describe how EMT may impact the metastatic process and resistance to therapy in hepatocellular carcinoma.
上皮-间质转化（EMT）是胚胎发育过程中发生的一个生理过程。在成年生物体中，EMT可能参与疾病的发展。在肝脏中，肝上皮细胞发生EMT参与肝纤维化的可能性正受到越来越多的讨论。此外，在过去几年中，肝细胞EMT参与肝癌生物学的情况也有文献记载。在本综述中，我们将首先描述EMT如何参与胚胎发育。然后，我们将讨论肝细胞和胆管上皮细胞在肝纤维化中的作用。最后，我们将描述EMT如何影响肝细胞癌的转移过程和对治疗的抵抗性。
