肾结石与心肌梗死风险增加相关。
Kidney stones associate with increased risk for myocardial infarction.
机构信息
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
J Am Soc Nephrol. 2010 Oct;21(10):1641-4. doi: 10.1681/ASN.2010030253. Epub 2010 Jul 8.
Kidney stones are a risk factor for chronic kidney disease (CKD), which, in turn, is a risk factor for myocardial infarction (MI). The objective of this study was to determine whether kidney stones associate with an increased risk for MI. We matched 4564 stone formers (1984 through 2003) on age and gender with 10,860 control subjects among residents in Olmsted County, Minnesota. We identified incident MI by diagnostic codes and validated events by chart review through 2006. We used diagnostic codes to determine incidence of kidney stones and presence of comorbidities (CKD, hypertension, diabetes, obesity, dyslipidemia, gout, alcohol dependence, and tobacco use). During a mean of 9 years of follow-up, stone formers had a 38% (95% confidence interval 7 to 77%) increased risk for MI, which remained at 31% (95% confidence interval 2% to 69%) after adjustment for CKD and other comorbidities. In conclusion, kidney stone formers are at increased risk for MI, and this risk is independent of CKD and other risk factors.
肾结石是慢性肾脏病（CKD）的一个危险因素，而 CKD 又是心肌梗死（MI）的一个危险因素。本研究旨在确定肾结石是否与 MI 风险增加相关。我们在明尼苏达州奥姆斯特德县的居民中，按年龄和性别匹配了 4564 名结石形成者（1984 年至 2003 年）和 10860 名对照者。我们通过诊断代码确定了 MI 的发病情况，并通过 2006 年的图表回顾验证了事件。我们使用诊断代码来确定肾结石的发生率和并存疾病（CKD、高血压、糖尿病、肥胖、血脂异常、痛风、酒精依赖和吸烟）的存在。在平均 9 年的随访期间，结石形成者发生 MI 的风险增加了 38%（95%置信区间为 7%至 77%），在调整 CKD 和其他并存疾病后，这一风险仍为 31%（95%置信区间为 2%至 69%）。总之，肾结石患者发生 MI 的风险增加，而且这种风险独立于 CKD 和其他危险因素。
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