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Alcohol and HCV chronic infection are risk cofactors of type 2 diabetes mellitus for hepatocellular carcinoma in Italy.在意大利，酒精和丙型肝炎慢性感染是导致肝细胞癌的 2 型糖尿病的共同危险因素。
Int J Environ Res Public Health. 2010 Apr;7(4):1366-78. doi: 10.3390/ijerph7041366. Epub 2010 Mar 29.
2
Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis.酒精性或病毒性丙型肝硬化患者肝细胞癌的危险因素。
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Diabetes Mellitus Heightens the Risk of Hepatocellular Carcinoma Except in Patients With Hepatitis C Cirrhosis.糖尿病会增加肝细胞癌的风险，但丙型肝炎肝硬化患者除外。
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Association between HCV and HBV infection in hepatocellular carcinoma and alcoholic liver disease.肝细胞癌和酒精性肝病中丙型肝炎病毒与乙型肝炎病毒感染之间的关联。
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Diabetes Mellitus Predicts Occurrence of Cirrhosis and Hepatocellular Cancer in Alcoholic Liver and Non-alcoholic Fatty Liver Diseases.糖尿病可预测酒精性肝病和非酒精性脂肪性肝病患者发生肝硬化和肝细胞癌的风险。
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Diabetes and cancer: A critical appraisal of the pathogenetic and therapeutic links.糖尿病与癌症：对发病机制及治疗关联的批判性评估
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Spatial analysis of the home addresses of hospital patients with hepatitis B infection or hepatoma in Shenzhen, China from 2010 to 2012.2010年至2012年中国深圳乙肝感染或肝癌住院患者家庭住址的空间分析。
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Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.丙型肝炎病毒与宿主的相互作用：病因发病机制及治疗策略。
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Diabetes and infections-hepatitis C: is there type 2 diabetes excess in hepatitis C infection?糖尿病与感染-丙型肝炎：丙型肝炎感染中是否存在 2 型糖尿病过度发生？
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本文引用的文献

1
Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy: potential role of insulin.意大利肝细胞癌与2型糖尿病之间的关联：胰岛素的潜在作用。
World J Gastroenterol. 2008 Oct 7;14(37):5695-700. doi: 10.3748/wjg.14.5695.
2
Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan.代谢因素与慢性乙型/丙型肝炎感染导致肝细胞癌的风险：台湾的一项随访研究
Gastroenterology. 2008 Jul;135(1):111-21. doi: 10.1053/j.gastro.2008.03.073. Epub 2008 Apr 4.
3
The growing burden of diabetes mellitus in the US elderly population.美国老年人群中糖尿病负担日益加重。
Arch Intern Med. 2008 Jan 28;168(2):192-9; discussion 199. doi: 10.1001/archinternmed.2007.35.
4
Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease.2型糖尿病患者的肝脏疾病谱以及糖尿病合并肝脏疾病患者的管理
Diabetes Care. 2007 Mar;30(3):734-43. doi: 10.2337/dc06-1539.
5
Diabetes and liver disease: an ominous association.糖尿病与肝脏疾病：一种不祥的关联。
Nutr Metab Cardiovasc Dis. 2007 Jan;17(1):63-70. doi: 10.1016/j.numecd.2006.08.004.
6
The metabolic syndrome is a risk indicator of microvascular and macrovascular complications in diabetes: results from Metascreen, a multicenter diabetes clinic-based survey.代谢综合征是糖尿病微血管和大血管并发症的风险指标：基于多中心糖尿病诊所调查的Metascreen研究结果
Diabetes Care. 2006 Dec;29(12):2701-7. doi: 10.2337/dc06-0942.
7
Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan.糖尿病与癌症风险：来自日本一项大规模基于人群的队列研究的结果。
Arch Intern Med. 2006 Sep 25;166(17):1871-7. doi: 10.1001/archinte.166.17.1871.
8
Type 2 diabetes and hepatocellular carcinoma: A cohort study in high prevalence area of hepatitis virus infection.2型糖尿病与肝细胞癌：一项在肝炎病毒感染高流行地区开展的队列研究
Hepatology. 2006 Jun;43(6):1295-302. doi: 10.1002/hep.21208.
9
Alcohol, vitamin A, and cancer.酒精、维生素A与癌症。
Alcohol. 2005 Apr;35(3):251-8. doi: 10.1016/j.alcohol.2005.04.006.
10
Alcohol, iron-associated oxidative stress, and cancer.酒精、铁相关氧化应激与癌症。
Alcohol. 2005 Apr;35(3):243-9. doi: 10.1016/j.alcohol.2005.03.013.

在意大利，酒精和丙型肝炎慢性感染是导致肝细胞癌的 2 型糖尿病的共同危险因素。

Alcohol and HCV chronic infection are risk cofactors of type 2 diabetes mellitus for hepatocellular carcinoma in Italy.

机构信息

Department of Medicine, Internal Medicine 3, Pordenone Hospital, Via Montereale 24, Pordenone 33170, Italy.

出版信息

Int J Environ Res Public Health. 2010 Apr;7(4):1366-78. doi: 10.3390/ijerph7041366. Epub 2010 Mar 29.

DOI:10.3390/ijerph7041366
PMID:20617035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2872357/
Abstract

Type 2 diabetes mellitus (DM2) has been associated with hepatocellular carcinoma (HCC) development. To study this relationship, we enrolled 465 HCC patients compared with 618 Cirrhotic cases and 490 Controls. The prevalence of DM2 is significantly higher in HCC patients with an Odds Ratio of 3.12 versus Controls. In HCC cases with alcohol abuse, the frequency of DM2 is the highest. In our HCC patients, when HCV infection is associated with alcohol abuse, the liver cancer develops earlier. In addition, multivariate analysis shows that alcohol consumption is an independent risk factor for HCC more relevant than HCV infection.

摘要

2 型糖尿病（DM2）与肝细胞癌（HCC）的发展有关。为了研究这种关系，我们招募了 465 名 HCC 患者与 618 名肝硬化病例和 490 名对照进行比较。与对照组相比，DM2 在 HCC 患者中的患病率明显更高，优势比为 3.12。在酒精滥用的 HCC 病例中，DM2 的频率最高。在我们的 HCC 患者中，当 HCV 感染合并酒精滥用时，肝癌的发生更早。此外，多变量分析表明，饮酒是 HCC 的独立危险因素，比 HCV 感染更相关。