近年来过渡金属催化叠氮化物 N-原子转移反应的研究进展。
Recent advances in transition metal-catalyzed N-atom transfer reactions of azides.
机构信息
University of Illinois at Chicago, Department of Chemistry, 845 W. Taylor St., Chicago, IL 60607, USA.
出版信息
Org Biomol Chem. 2010 Sep 7;8(17):3831-46. doi: 10.1039/c005219c. Epub 2010 Jul 8.
Abstract
Transition metal-catalyzed N-atom transfer reactions of azides provide efficient ways to construct new carbon-nitrogen and sulfur-nitrogen bonds. These reactions are inherently green: no additive besides catalyst is needed to form the nitrenoid reactive intermediate, and the by-product of the reaction is environmentally benign N(2) gas. As such, azides can be useful precursors for transition metal-catalyzed N-atom transfer to sulfides, olefins and C-H bonds. These methods offer competitive selectivities and comparable substrate scope as alternative processes to generate metal nitrenoids.
摘要
过渡金属催化的叠氮化物 N-原子转移反应为构建新的碳-氮和硫-氮键提供了有效的方法。这些反应本质上是绿色的：形成氮宾反应活性中间体除了催化剂之外不需要添加任何其他添加剂，并且反应的副产物是环境友好的 N(2)气体。因此，叠氮化物可以作为过渡金属催化的 N-原子转移到硫化物、烯烃和 C-H 键的有用前体。这些方法提供了有竞争力的选择性和可比较的底物范围，是生成金属氮宾的替代方法。
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