比马前列素 0.03%凝胶用于美容睫毛生长和增强。
Bimatoprost 0.03% gel for cosmetic eyelash growth and enhancement.
机构信息
Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA.
出版信息
J Cosmet Dermatol. 2010 Jun;9(2):96-102. doi: 10.1111/j.1473-2165.2010.00487.x.
OBJECTIVE
To evaluate a bimatoprost gel for enhancing eyelash growth, adverse effects, and change in intraocular pressure (IOP).
METHODS
Prospective, double-masked, randomized controlled study. Fifty-two patients without ocular disease were assigned a control or bimatoprost 0.03% gel to apply to the eyelid margin once a day.
RESULTS
The adjusted mean change in eyelash length from baseline to 6 months was 0.77 mm in the bimatoprost group and -0.12 mm in the control group (P = 0.004). Adverse effects were experienced by 2 of 16 patients (12.5%) in the control group and 9 of 36 patients (25%) in the bimatoprost gel group. Mean change in IOP from baseline to 6 months was 0.685 mmHg in the control group and -2.04 mmHg in the bimatoprost group (P = 0.009).
CONCLUSIONS
Bimatoprost gel was effective in enhancing eyelash growth. The most common adverse effect for the bimatoprost gel was conjunctival and eyelid hyperemia, while the most severe was recurrent anterior uveitis. Mean IOP was reduced in subjects using the bimatoprost gel.
目的
评估一种比马前列素凝胶促进睫毛生长、不良反应和眼压（IOP）变化的效果。
方法
前瞻性、双盲、随机对照研究。52 名无眼部疾病的患者被分配到对照组或比马前列素 0.03%凝胶组，每天一次涂抹于眼睑边缘。
结果
从基线到 6 个月时，睫毛长度的调整平均变化在比马前列素组为 0.77mm，在对照组为-0.12mm（P=0.004）。对照组有 2 名患者（12.5%）出现不良反应，比马前列素凝胶组有 9 名患者（25%）出现不良反应。从基线到 6 个月时，对照组的 IOP 平均变化为 0.685mmHg，比马前列素组为-2.04mmHg（P=0.009）。
结论
比马前列素凝胶可有效促进睫毛生长。比马前列素凝胶最常见的不良反应是结膜和眼睑充血，最严重的是复发性前葡萄膜炎。使用比马前列素凝胶的受试者的平均眼压降低。
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