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RNA 稳定性的全球动态调控着细胞激活的反应。

The global dynamics of RNA stability orchestrates responses to cellular activation.

机构信息

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

BMC Biol. 2010 Jul 8;8:95. doi: 10.1186/1741-7007-8-95.

DOI:10.1186/1741-7007-8-95
PMID:20619007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2900241/
Abstract

Transcriptomics is used to quantify changes in accumulated levels of mRNAs following cellular activation. These changes arise from the opposing fluxes of transcription and mRNA decay, both of which affect the functional dynamics of global gene expression. A study published recently in BMC Genomics focuses on the contribution made by mRNA stability in shaping the kinetics of gene responses in mammalian cells.

摘要

转录组学用于定量分析细胞激活后 mRNA 积累水平的变化。这些变化源于转录和 mRNA 降解的相反通量，它们都影响全局基因表达的功能动态。最近在 BMC 基因组学上发表的一项研究关注了 mRNA 稳定性在塑造哺乳动物细胞中基因反应动力学方面的贡献。

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Genome-wide analysis shows that RNase G plays a global role in the stability of mRNAs in Stenotrophomonas maltophilia.全基因组分析表明，RNase G 在嗜麦芽寡养单胞菌中 mRNA 稳定性方面发挥着全局作用。
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