Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain.
Eur J Med Chem. 2010 Sep;45(9):4258-69. doi: 10.1016/j.ejmech.2010.06.025. Epub 2010 Jun 23.
Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active.
已经合成了几种类异戊烯基黄酮，并对人肿瘤细胞系进行了测试。异戊烯基为香叶基或角鲨烯二萜烯。这些角鲨烯类黄酮是首次合成的。在 C-8 位的异戊烯化增加了抗肿瘤活性。还合成了 23 种 C 和 O 异戊烯基酰基间苯三酚。在这种情况下，C-烷基化产物通常更具活性。
