Sato Y, Ogata E, Fujita T
Fourth Department of Internal Medicine, School of Medicine, University of Tokyo, Japan.
Jpn Circ J. 1991 May;55(5):500-8. doi: 10.1253/jcj.55.500.
We studied the roles of the sympathoadrenal system and endogenous opiate in the antihypertensive effects of supplementation of dietary taurine, a sulfur amino acid, in deoxycorticosterone acetate (DOCA)-salt rats. Supplementation of 1% taurine in drinking water for 2 weeks was found to prevent the increase in systolic blood pressure of DOCA-salt rats (116 +/- 2 vs 138 +/- 2 mmHg, p less than 0.01), but failed to effect the systolic blood pressure of vehicle-treated control rats (115 +/- 2 vs 112 +/- 3 mmHg), taurine supplementation restored to normal increased plasma norepinephrine (326 +/- 32 vs 531 +/- 67 pg/ml, p less than 0.01) and epinephrine (204 +/- 19 vs 304 +/- 43 pg/ml, p less than 0.05) concentrations in DOCA-salt rats, but had no effect on norepinephrine (346 +/- 23 vs 338 +/- 33 pg/ml) or epinephrine (198 +/- 17 vs 224 +/- 26 pg/ml) concentrations in control rats. Accordingly, the increased epinephrine content in the adrenals of DOCA-salt rats was normalized with the supplementation of taurine, associated with a markedly increased adrenal taurine content. In conscious rats, moreover, intraperitoneal injection of naloxone (2 mg/kg), a specific opiate antagonist, increased systolic blood pressure only in taurine-supplemented DOCA-salt rats. Evidence presented suggests, therefore, that both the suppression of the increased sympathoadrenal activity and the activation of endogenous opiate might contribute to the antihypertensive effect of taurine in DOCA-salt rats.
我们研究了交感肾上腺系统和内源性阿片肽在补充膳食牛磺酸（一种含硫氨基酸）对醋酸脱氧皮质酮（DOCA）-盐大鼠降压作用中的作用。结果发现，在饮用水中补充1%牛磺酸2周可防止DOCA-盐大鼠收缩压升高（116±2 vs 138±2 mmHg，p<0.01），但对给予赋形剂处理的对照大鼠的收缩压无影响（115±2 vs 112±3 mmHg）。补充牛磺酸可使DOCA-盐大鼠升高的血浆去甲肾上腺素（326±32 vs 531±67 pg/ml，p<0.01）和肾上腺素（204±19 vs 304±43 pg/ml，p<0.05）浓度恢复正常，但对对照大鼠的去甲肾上腺素（346±23 vs 338±33 pg/ml）或肾上腺素（198±17 vs 224±26 pg/ml）浓度无影响。因此，补充牛磺酸可使DOCA-盐大鼠肾上腺中升高的肾上腺素含量恢复正常，同时肾上腺牛磺酸含量显著增加。此外，在清醒大鼠中，腹腔注射特异性阿片拮抗剂纳洛酮（2 mg/kg）仅使补充牛磺酸的DOCA-盐大鼠的收缩压升高。因此，现有证据表明，抑制交感肾上腺活性增加和激活内源性阿片肽可能都有助于牛磺酸对DOCA-盐大鼠的降压作用。
