Department of Pediatrics, University of Tennessee Health Science Center, and the Children's Foundation Research Center at Le Bonheur Children's Medical Center, 50 N, Dunlap, Memphis, Tennessee 38103, USA.
J Biomed Sci. 2010 Aug 24;17 Suppl 1(Suppl 1):S4. doi: 10.1186/1423-0127-17-S1-S4.
Taurine participates in a number of different physiologic and biologic processes in the kidney, often reflected by urinary excretion patterns. The kidney is key to aspects of taurine body pool size and homeostasis. This review will examine the renal-taurine interactions relative to ion reabsorption; renal blood flow and renal vascular endothelial function; antioxidant properties, especially in the glomerulus; and the role of taurine in ischemia and reperfusion injury. In addition, taurine plays a role in the renal cell cycle and apoptosis, and functions as an osmolyte during the stress response. The role of the kidney in adaptation to variations in dietary taurine intake and the regulation of taurine body pool size are described. Finally, the protective function of taurine against several kidney diseases is reviewed.
牛磺酸参与肾脏的许多不同生理和生物学过程，通常反映在尿排泄模式上。肾脏是牛磺酸体池大小和体内平衡的关键。本综述将检查与离子重吸收、肾血流量和肾血管内皮功能、抗氧化特性（特别是在肾小球中）以及牛磺酸在缺血再灌注损伤中的作用有关的肾-牛磺酸相互作用。此外，牛磺酸在肾细胞周期和细胞凋亡中发挥作用，并在应激反应中作为渗透调节剂发挥作用。描述了肾脏在适应膳食牛磺酸摄入量变化和调节牛磺酸体池大小中的作用。最后，综述了牛磺酸对几种肾脏疾病的保护作用。
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