Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA.
Curr Biol. 2010 Jun 22;20(12):R515-7. doi: 10.1016/j.cub.2010.05.033.
In yeast, phosphorylation of the Sld3 protein by cyclin-dependent kinases is essential for replication initiation. In metazoans, three potential Sld3 counterparts have emerged. A new study suggests that one of these, Treslin/Ticrr, is the Sld3 ortholog.
在酵母中，细胞周期蛋白依赖性激酶对 Sld3 蛋白的磷酸化对于复制起始至关重要。在后生动物中，出现了三个潜在的 Sld3 对应物。一项新的研究表明，其中之一 Treslin/Ticrr 是 Sld3 的直系同源物。
