Negi R R, Gupta Manish, Kumar Muninder, Gupta M K, Seam R, Rastogi Madhup
Department of Radiotherapy & Oncology, IGMC, Shimla, HP, India.
J Cancer Res Ther. 2010 Apr-Jun;6(2):159-66. doi: 10.4103/0973-1482.65240.
To investigate the feasibility of concurrent chemo radiation in locally advanced carcinoma cervix patients in our clinical setting.
From Sept. 1st 2005 to Aug. 31st 2006, 102 patients of carcinoma cervix belonging to stage IIA to IV A were enrolled in the study. External beam radiation therapy was administered using Cobalt 60 teletherapy machine. Cisplatinum (40 mg/m 2) and 5 Fluorouracil (500 mg/m 2 ) continuous infusions with radiotherapy on D2-D5 in first and last 5 # of radiation therapy were administered.
Response to treatment and toxicities were monitored and analyzed in 102 patients (50 study group and 52 control group). All 102 patients completed treatment. Out of 50 patients in the study group, 30, 10 and 4 patients had complete, partial and progressive disease, respectively. While out of 52 patients in the control group, 26 had complete and 12 showed partial response. No difference in overall renal, hematological and cutaneous toxicity was seen between two groups.
This study did not show any benefit of concurrent chemo radiation as compared to radiotherapy alone in locally advanced cervical cancer patients. This could be due to more bulk of tumor stage per stage, poor nutritional status, less number of patients in both arms, not enough to pick up statistically significant small difference in outcome.
在我们的临床环境中研究同步放化疗在局部晚期宫颈癌患者中的可行性。
2005年9月1日至2006年8月31日，102例IIA至IVA期宫颈癌患者纳入本研究。使用钴60远距离治疗机进行外照射放疗。在放疗的第1个和最后5次的第2至5天给予顺铂（40mg/m²）和5-氟尿嘧啶（500mg/m²）持续静脉输注并联合放疗。
对102例患者（50例研究组和52例对照组）的治疗反应和毒性进行了监测和分析。所有102例患者均完成治疗。研究组的50例患者中，分别有30例、10例和4例患者达到完全缓解、部分缓解和病情进展。而对照组的52例患者中，26例达到完全缓解，12例显示部分缓解。两组在总体肾脏、血液学和皮肤毒性方面未见差异。
本研究未显示同步放化疗相比于单纯放疗对局部晚期宫颈癌患者有任何益处。这可能是由于每个分期的肿瘤体积更大、营养状况差、两组患者数量较少，不足以发现结局中具有统计学意义的微小差异。
